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Drug Use Articles & Analysis
244 articles found
An estimated 15.5 million adults have used a GLP-1 drug, and awareness is high: about 75% of Americans are familiar with GLP-1 therapies, and more than half view them as a strong option for obesity-related health management. ...
Many oncology drugs have been abandoned by pharmaceutical companies due to poor performance in phase I, II, or III clinical trials. These drugs represent untapped potential treatments for indications outside of those initially investigated. With research and development costs for a single new drug estimated between $2–3 billion, abandoned drugs represent an opportunity to bring drugs to ...
Chemical Synthesis Chemical synthesis remains one of the most widely used techniques for lipid production due to its versatility and control over molecular structure. ...
This article explores the mechanisms, benefits, challenges, and future prospects of PEGylation in drug development. Mechanism of PEGylation PEGylation involves the covalent or non-covalent attachment of PEG—a synthetic, hydrophilic polymer—to a drug molecule. The process typically uses reactive PEG derivatives (e.g., methoxy-PEG or ...
Platelet drug delivery systems will use platelets or their derivatives for creating specific drug carriers which can target matching cells to execute drug delivery functions and develop new treatment strategies. Current research directions for this drug system involve the following topics. Platelets Directly ...
The MDCK permeability assay is a critical technique employed in pharmacology and drug development to evaluate the permeability of drug candidates across epithelial cell layers. ...
l Wound Healing: bioglass has been shown to promote wound healing by stimulating the growth of new tissue. It is used in dressings and other wound care products. l Drug Delivery: Researchers are exploring the use of bioglass as a drug delivery system. ...
ByMatexcel
One such advancement is the establishment of the Monkey DLL3 stable cell line using HEK293T cells. This article provides an overview of the significance of this cell line, its applications, and the methodology behind its development. ...
Preclinical drug discovery represents a critical phase in the development of new therapeutics. ...
Various species, including rodents, primates, and even larger mammals, are employed depending on the disease context and research requirements. Types of Animal Models Used in Drug Screening Diverse animal models are utilized in drug screening, with each offering unique advantages. ...
One notable case is the development of antiviral agents, where phosphorus compounds serve as critical intermediates. The synthesis of drugs targeting viral infections often involves the use of phosphoramidites, which are derived from phosphorus oxychloride. ...
They are FDA-approved and often used in various applications, from sutures to drug delivery systems. ...
The evolution of 3D printing technology has opened up new avenues in the pharmaceutical industry, especially in the fabrication of novel drug delivery systems. One such advancement is the 3D printing of Oral Thin Films (OTFs), which are ultra-thin films used to deliver drugs via oral mucosa. ...
This process allows the cells to proliferate, creating a consistent source of experimental material for various studies. The most commonly used colorectal cancer cell lines include HCT116, SW480, and HT-29, each with distinct genetic and phenotypic characteristics. Applications in Research Colorectal cancer cell lines are instrumental in various research applications. One of the ...
The evaluation of cardiovascular toxicity is a significant challenge in drug development. Preclinical evaluation of cardiovascular safety involves a multifaceted approach, encompassing a plethora of in vitro and in vivo endpoints. These assessments continuously evolve, aiming to mitigate the incidence of cardiovascular toxicity that may emerge during clinical trials. To shed light on the ...
At present, recombinant protein drugs are widely used in various fields such as tumors, autoimmune diseases, metabolic diseases, geriatric diseases, and degenerative diseases.FcyR (Fc gamma receptors) are receptors expressed on the surface of immune cells, primarily responsible for recognizing and binding to the Fc (Fragment crystallizable region) part of ...
Condensation Polymerization: In this method, copolymers are formed by the reaction between two different monomers, typically involving the elimination of a small molecule (such as water). This process is commonly used in producing polyesters and polyamides and is advantageous for creating specialty copolymers. ...
This method involves conducting the reaction in solution, with protective groups used to prevent unwanted side reactions. Applications of Synthetic Peptides The versatility of synthetic peptides allows them to serve numerous roles across various fields: Pharmaceutical Development One of the most significant applications of synthetic peptides is in drug ...
Peptide drugs are bioactive protein fragments composed of short chains of amino acids. ...
In light of the recent act that has just come into force, the use of electronic cigarettes is now going to be heavily regulated. Although Malaysia has not banned the use of e-cigarettes like some neighbouring countries, the stricter regulations present a challenging position within the region regarding this issue. ...