Refine by
G Protein Coupled Receptor Articles & Analysis
10 articles found
Lipids are not merely structural components of cellular membranes—they also act as powerful signaling molecules that orchestrate key physiological processes. Among the enzymes regulating lipid signaling, ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2), also known as autotaxin, plays a central role by converting lysophosphatidylcholine (LPC) into the bioactive lipid ...
Chemokines and their receptors form one of the most intricate signaling networks in immunology. Among them, CCR1 (C-C chemokine receptor type 1) has attracted attention for its dual role as both a guardian of host defense and a potential driver of chronic inflammation and cancer progression. For researchers, CCR1 is more than a seven-transmembrane G protein–coupled receptor (GPCR)—it ...
Chemokines are a specialized subset of small cytokines that play a crucial role in the immune system by directing the movement of circulating leukocytes to sites of inflammation, infection, and injury. Acting as chemoattractant molecules, chemokines are central to both innate and adaptive immunity, influencing not only immune surveillance but also wound healing and angiogenesis. Over the past few ...
Understanding the complex world of drug discovery and development necessitates familiarity with key players in cellular communication. A pivotal group in this arena is G Protein-Coupled Receptors (GPCRs). These receptors play a crucial role in transmitting signals across cell membranes, significantly influencing numerous physiological processes. Consequently, GPCRs have become a central focus in ...
What is CD73? CD73, also known as ecto-5′-nucleotidase, is a groundbreaking immunoinhibitory protein that assumes a pivotal role in tumor growth and metastasis. Its primary function revolves around converting extracellular ATP into immunosuppressive adenosine, working in tandem with CD39 within normal tissues to curtail excessive immune reactions. However, this mechanism is often hijacked ...
Why target GPCRs with antibodies? The G Protein-coupled receptor (GPCR) superfamily represents the largest and single most important family of human drug targets. GPCRs play a central role in a plethora of biological processes and are linked to a wide range of therapeutic areas including cancer, diabetes, inflammation, cardiovascular diseases, and chronic pain. Expressed in every type of cell in ...
Focal Molography, a Guide Inside Cellular Pathways There are billions of cells in our bodies, each with their own characteristics and functions. To function together, cells need to communicate; during the evolution of multi-cellular organisms, cells have developed communication systems of exceptional complexity. These systems govern every level of communication, and together they dictate cell ...
Fatty acids, along with glucose and amino acids, are the main source of energy for cell growth and proliferation. Abnormalities in fatty acid metabolism are commonly seen in cancer. A growing number of studies have shown that increased ab initio synthesis of fatty acids in tumor cells is a prominent feature in the development of cancer. And the activation of ab initio synthesis is negatively ...
There are docking stations called receptors on the surface of our cells. Various compounds ranging from caffeine and dopamine to heroin, tetrahydrocannabinol (THC) and lysergic diethylamine (LSD) all bind to these receptors. Indeed, G protein-coupled receptors are the intended target of action for more than 30% of drugs currently on the market. But these drugs often also target unintended targets ...
Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38) is a potent neuropeptide that acts through G-protein-coupled receptors. While it is well established that PACAP mediates both neurotrophic and neurodevelopmental effects, the signaling cascades that underlie these diverse actions remain incompletely characterized. Here we show that the Ras-related Rin GTP-binding protein, a GTPase ...