g-protein-coupled-receptor Downloads
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Description: Human CXCL1 is a 73 amino acid, ELR+ chemokine that belongs to the GRO isoform subset which activate the G protein-coupled receptor CXCR2. TNF-stimulated epithelial cells strongly express CXCL1 in addition to the constitutive expression by macrophages. CXCL1 is a potent chemoattractant for neutrophils and an activator of basophils. ...
Human CX3CL1 is a membrane protein consisting of a mucin-like stalk attached to a transmembrane domain containing a C-terminal tail. CX3CL1 is the ligand to the G protein-coupled receptor CX3CR1. CX3CL1 and its receptor have been shown to be a involved in the cellular processes leading to atherosclerosis, where a deletion of the gene specific to the CX3CR1 receptor in transgenic mouse models lead ...
Human CCL2, also designated Monocyte chemotactic protein 1 (MCP-1), Monocyte chemotactic and activating factor (MCAF) and JE, chemoattracts mononuclear cells through activation of the G protein-coupled receptor CCR2. The N-terminal glutamine of CCL2 undergoes post-translational modification to pyroglutamic acid. Macrophages and monocytes are the primary producers of CCL2. ...
CCL17, also known as TARC, is constitutively expressed in the thymus and can be upregulated in peripheral blood mononuclear cells. CCL17 is a ligand for the G protein coupled receptors CCR4 and CCR8, and induces chemotactic migration for T lymphocytes, but not monocytes or granulocytes. ...
CXCL12 is a ligand for the G protein coupled receptor CXCR4 and induces chemotactic migration in a wide range of CXCR4-expressing cells. CXCL12 protein is expressed in E. coli, refolded and cleaved to yield the native, secreted form of the mature ...
Human CXCL2 is a 73 amino acid, ELR+ chemokine that belongs to the GRO isoform subset which activates the G protein-coupled receptors CXCR2. LPS-stimulated macrophages strongly express CXCL2 in addition to the constitutive expression by macrophages. CXCL1 is a potent chemoattractant for neutrophils and hematopoietic stem cells and an activator of basophils. ...
Human CXCL4, additionally known as Platelet-factor 4, is a 70 amino acid protein that is released by activated platelets to promote coagulation. CXCL4 binds to the G protein-coupled receptor CXCR3-B, found in kidney, heart and liver tissue, but a canonical signaling receptor is still unknown. CXCL4 readily binds to heparin-like molecules and glycoproteins and is a regulator of endothelial and ...
Human CCL5, also known as Regulated upon Activation, Normal T cell Expressed and presumably Secreted (RANTES), attracts and activates leukocytes and plays a primary role in the inflammatory immune response. CCL5 activates several G protein-coupled receptors including CCRs 1, 3, 4, and 5. CCL5 binding to CCR5 inhibits the infectivity of M-tropic HIV-1 strains. Proteolytic removal of the two ...