Genotoxicity Articles & Analysis
9 articles found
Our company provides qualitative detection methods (direct contact, AGAR diffusion or MEM elution) and quantitative detection methods (MTT assay). Genotoxicity testingWe conducted a series of in vitro and in vivo tests to examine whether medical devices contain substances that can directly or indirectly induce genetic damage through a variety of mechanisms. The methods used to ...
A key characteristic of rAAV particles is the ability of the incorporated gene to remain episomal and persist as long-lasting expression without integrating into the host genome, thus avoiding potential genotoxicity. On the other hand, the recombinase field has rapidly advanced and expanded the applications of rAAVs. ...
Both tumour cell lines were able to repair a considerable part of the radioinduced damage within 1 h after exposure, indicating a relative radioresistance of these cell lines to the genotoxic action of ionising radiation.Keywords: micronucleus, breast cancer, irradiation, comet assay, DNA damage, T-47D, MCF-7, cancer cells, ionising radiation, low radiation, cancer treatment, ...
The present work evaluates the radioprotective effect of curcumin on γ-radiation-induced genetic toxicity. The DNA damage was analysed by the frequencies of Sister Chromatid Exchanges (SCEs). Human lymphocytes were treated in vitro with 5.0 γg/ml of curcumin for 30 min at 37°C then exposed to 1, 2 and 4 Gy γ-radiation. The lymphocytes were cultured in (RPMI) 1640 tissue culture medium and ...
The contamination effects on soil functional qualities and plant nutrition were evaluated; furthermore DNA damage with short-term genotoxicity tests and DNA biosensor on polluted soils and gravitational water, was detected. The genotoxic effects were evaluated on Vicia faba seedlings by two different short-term tests: comet assay and micronuclei test. A DNA-based ...
3 X.Keywords: micronucleus assay, octreotate, somatostatin, human lymphocyte, 131I, 177Lu, DNA damage, genotoxic evaluation, low radiation, cytogenetic effect, blood cells, radioactive concentrations, binucleated ...
Ames' mutagenicity and micronucleus genotoxicity tests came out negative at 50 mg and 2000 mg/kg doses in Salmonella and bone marrow of IRC mice. ...
Based on the analyses of most published studies, it is still unclear if EMFs are significant risk factors for human health and the necessity of new directions for EMF research in the areas of epidemiology, exposure metrics, animal studies and biophysics appear requested.Keywords: electromagnetic fields, genotoxic effect, heat shock proteins, electric fields, magnetic fields, risk ...
Organic contaminants are continually entering aquatic environments and thence the tissues of resident biota. Mussels and other molluscs are used worldwide as sentinels in pollution monitoring. Recent years have seen the development of biological measurements (biomarkers) as tools for use in monitoring and environmental impact assessment, such biomarkers being indicative of contaminant exposure ...