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Genotoxicity Services
6 services found
Manufactured by:Gentronix Ltd based inCheshire, UNITED KINGDOM
The mouse lymphoma assay is one of the mammalian gene mutation assays available and is frequently utilised in most genotoxicity testing regulatory frameworks. Able to detect point mutations, clastogens, and in some cases aneugens; the mouse lymphoma assay has an advantage compared to the HPRT (the alternative mammalian gene mutation assay) due to its capability to detect a ...
Manufactured by:Gentronix Ltd based inCheshire, UNITED KINGDOM
The in vitro micronucleus test (MNT) is a main-stay of most regulatory genotoxicity testing strategies, and is used to detect in vitro clastogens and aneugens. In this regard it complements the Ames test well, as between the two study types they detect all of the three major classes of genotoxin. Fluorescence In Situ Hybridisation (FISH) can also be conducted to differentiate ...
Manufactured by:Regis Technologies Inc. based inMorton Grove, ILLINOIS (USA)
Regulatory agencies have acknowledged impurities, especially potential genotoxic impurities (PGIs), as a high priority in the drug development approval process. Since impurities found in pharmaceutical drug substances can potentially exhibit pharmacological activity, there are reporting, identification, and qualification thresholds dictated by ICH guidelines. ...
Manufactured by:Echelon Biosciences, Inc (EBI) based inSalt Lake City, UTAH (USA)
The Hyaluronic Acid (HA) Screening Service uses the HA-ELISA kit (K-1200) to quantify HA in biological samples. Hyaluronic acid (HA) is a high molecular weight anionic polysaccharide (1,000-10,000 kD) composed of repeating disaccharides. Many chronic liver diseases, including infection, toxicity, genetic, autoimmunity, and malignancy result in liver inflammation and an increase in circulating HA ...
Manufactured by:InnoSer Belgie NV based inDiepenbeek, BELGIUM
In vitro and in vivo methods to provide a study setup that thoroughly determines safety and efficacy. ...
Manufactured by:InnoSer Belgie NV based inDiepenbeek, BELGIUM
We move your identified hits forward into in vivo testing and lead optimization. As a critical phase in your drug development journey, the hit to lead phase will determine which of your promising compounds will be characterized against your targets. With a lean ethos, InnoSer is dedicated to combining our expertise with your drug development goals in the most resource efficient way. During this ...