Human Immunodeficiency Virus Articles & Analysis
10 articles found
Biomedical liquid waste originating from healthcare facilities, laboratories, and research centers often contains infectious materials that, when discharged without proper treatment, can contribute to the spread of communicable diseases through public sewers. These diseases can affect individuals coming into contact with contaminated water sources ...
Introduction of Drug Affinity Responsive Target Stability (DARTS) Drug target protein identification is an important step in the research and development of new drugs. Drug Affinity Response Target Stability (DARTS) is a technique that can rapidly and directly identify potential target proteins of small molecule drugs. That is, it prevents the target protein from being hydrolyzed by proteases ...
Induced pluripotent stem cells (iPSCs) can be generated from a wide range of fully differentiated cells and, under optimal conditions, can potentially be driven to differentiate into virtually any fate. Induced stem-like cells not only provide an alternative to embryonic stem cells but more importantly represent a powerful tool for drug development and disease modeling. Methods to induce ...
The Challenge Every 60 minutes, of every day, six people suffer a needlestick injury somewhere in the world. Every day, 3 people die as a result of those injuries[1]. The World Health Organisation (WHO) reports in the World Health Report 2002, that of the 35 million health-care workers world wide, two million experience percutaneous exposure to infectious diseases each year[2]. WHO estimates ...
Human immunodeficiency virus (HIV) infected people have substantially greater need for water, sanitation and hygiene (WASH). Many opportunistic infections cause high morbidity and mortality in people living with HIV (PLHIV) than in immune competent populations. The objective of the study was to assess WASH practices and associated factors among PLHIV. A cross-sectional study design was ...
This article examines HIV transmission jurisprudence in the Australian state of Victoria. It details the development of criminal legislation to respond to the issue of HIV and the application of these offences to prosecute charges of HIV transmission in Victoria. It also outlines the case law in Victoria. The article questions the juridical handling of consensual sexuality and HIV risk, within ...
Poorly managed healthcare can be directly attributed to extensive drug regimens. Numerous chronic illnesses and epidemics such as HIV/AIDS and tuberculosis require elaborate drug regimens for efficacious therapeutic outcomes. Various drug delivery systems have been developed to simplify their regimental drug therapy. However, more effective and innovative drug delivery technologies are required ...
Women are at significant risk of heterosexually transmitted human immunodeficiency virus (HIV) infection, with the mucosal epithelium of the cervix and vagina serving as a major portal of entry. The cervicovaginal mucosa naturally harbors dynamic microflora composed predominantly of lactobacilli, which may be genetically modified to serve as a more efficient protective barrier against the ...
Toxoplasma gondii is an intracellular parasite with a significant impact on human health, especially in cases where individuals are immunocompromised (e.g., due to human immunodeficiency virus/AIDS). In Europe and North America, only a few clonal genotypes appear to be responsible for the vast majority of Toxoplasma infections, and these clonotypes have been intensely studied to identify ...
The safety of V-1 Immunitor (V1) has been investigated. L929; BHK; Vero; Caco-2 and CEM-SS cells have not shown cytotoxicity even at 10 mg/ml dose. Ames' mutagenicity and micronucleus genotoxicity tests came out negative at 50 mg and 2000 mg/kg doses in Salmonella and bone marrow of IRC mice. Acute and chronic dosing of V1 to Swiss albino mice and Spague Dawley rats failed to cause any deaths. ...