Igg1 Articles & Analysis
6 articles found
The constant region usually contains a set of constant amino acid sequences, which determine the class (such as IgG, IgA, IgM, etc.) and subtype (such as IgG1, IgG2, etc.) of the antibody.Importance of Antibody Constant Region Sequence Analysis1. ...
In this case, using the bispecific antibody helped reduce unexpected toxicity in patients with low levels of HER2 expression. l Selection of antibody size/fragment Most anti-tumor ADCs are based on IgG1 antibodies, partly because these molecules can trigger Fc-mediated immune functions such as ADCC, CDC, and ADCP. ...
At present, ADC drugs mostly use IgG1 molecules in humanized monoclonal antibody subtypes. Its advantage is that it has a higher affinity for the target antigen and a longer half-life in the blood. Compared with other IgG molecules, IgG1 has multiple natural sites for coupling, has better binding activity and is easier to produce, and is mostly the first choice ...
STEAP1 is an ion/protein transporter and an ideal target for ADCs because it is highly expressed in PCa cells but very low in normal tissues. DSTP3086S, a humanized IgG1 anti-steap1 monoclonal antibody related to MMAE, demonstrated safety and significant antitumor activity in a Phase I trial of 77 mCRPC patients. ...
Change disulfide bond to reduce cysteine coupling Taking IgG1 as an example, there are 4 pairs of interchain disulfide bonds that can be reduced, and 8 cysteine sulfhydryl groups are obtained after reduction. ...
Age‐adjusted linear regression models showed statistically significant positive associations between exposure to one or more of the PFC totals and/or individual analytes and the following immunological parameters: absolute numbers of CD2+ T cells, CD4+ helper T cells, CD19+ immature B cells, CD21+ mature B cells, CD2/CD21 ratio, MHCII+ cells, B cell proliferation, serum IgG1, ...