Induced Inflammation Articles & Analysis
13 articles found
While the dangers of primary smoking are well-known, nearly half of the U.S. population remains at risk from the silent threat of secondhand smoke (SHS). Chronic exposure to SHS triggers a cascade of inflammation and vascular damage that can lead to irreversible conditions like COPD and emphysema. A recent study from Sturgis et al. (2025) has demonstrated a promising new therapeutic candidate: ...
Evaluating the stress related effects of various restraint methods in rodents Any restraining device used in an inhalation exposure set-up will be, by definition, restricting the subject’s ability to move. For nose-only inhalation set-ups, typical restraints are rigid, fully enclosed and include a metal or acrylic plunger forcing the subject forward and preventing the subject from ...
Tumor Necrosis Factors (TNFs): TNFs are potent proinflammatory cytokines that are involved in a variety of immune responses, including inflammation, apoptosis, and cell differentiation. Chemokines: Chemokines are specialized cytokines that direct the migration of immune cells towards sites of infection or inflammation. ...
Upon intravenous injection in mice with dextran sulfate sodium-induced colitis, this surface-modified LNP actively targeted Ly6c+ white blood cells and induced IL-10 production, significantly suppressing inflammation in the colon. 2) T cell-targeted LNP Cardiac fibrosis is caused by excessive production of extracellular matrix by cardiac ...
Introducing post-translational modifications to peptide vaccines may also further enhance their effectiveness.The Use of AdjuvantsAdjuvants are substances co-administered with vaccines to stimulate antigen presentation and enhance immune efficacy. They reduce the antigen dose, induce rapid induction, and sustain B and T cell persistence. Most adjuvants induce ...
Trofinetide plays a multifaceted role in reducing inflammation, excitotoxic-induced tissue damage and apoptosis, thereby protecting neurons and their surrounding underlying tissues. 2. ...
PeptiStrong helps minimize muscle loss, support muscle synthesis and decrease exercise-induced inflammation with cell-signaling power that helps the body function. ...
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Besides the IL-2RG receptor subunit, the γc family cytokine receptors include IL-2RB ...
January 6, 2022—Researchers at the Perelman School of Medicine at the University of Pennsylvania published a research paper in Science titled: CAR-T cells produced in vivo to treat cardiac injury. Heart damage or inflammation can induce fibroblasts to overproduce fibrous material, causing cardiac fibrosis, which hardens the heart muscle and impairs heart ...
” Limitations of Animal Models The obvious approach to study intestinal inflammation is to make an animal model; however, to generate animal models of intestinal diseases involving inflammation, it is first necessary to induce damage in a manner similar to disease initiation. Since the etiology of IBD is unknown, this is challenging ...
Preclinical models and biomarkers have identified several likely pathways, apparently involving mitochondrial injury, inflammation, cellular death, and profibrotic. The cardiac consequences of AKI may be mediated by galectin-3 (Gal-3), as shown in studies of mice with AKI in which Gal-3 induced cardiac inflammation, cardiac fibrosis, and cardiac ...
Mice with Dermatophagoides farinaeextract (DFE)-induced AD were fed 1 × 109 CFU d−1 ofL. paracasei KBL382 for 4 weeks. ...
Highly diverse Lactobacillus-non-dominant vaginal microbial communities are strongly correlated with genital inflammation, which negatively affects reproductive health and increases the risk of HIV infection4,5. ...