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Kidney Disease Articles & Analysis
41 articles found
Pathologists and researchers utilize these blocks to conduct histological studies, enabling the identification of kidney diseases, such as glomerulonephritis and diabetic nephropathy. By examining tissue sections under a microscope, scientists can assess changes in kidney morphology and cellular composition, leading to a better understanding of ...
In soft tissues like arteries, unregulated hydroxyapatite accumulation leads to vascular calcification, a pathological condition associated with atherosclerosis, diabetes, chronic kidney disease (CKD), and aging. Studies in MGP-knockout mice have shown extensive arterial calcification and premature death, underscoring the importance of this protein in ...
Dysfunction of podocytes is linked to various kidney diseases, including diabetic nephropathy, focal segmental glomerulosclerosis, and minimal change disease. ...
These unique cells have garnered significant attention in scientific research due to their pivotal function in maintaining kidney health and their involvement in various kidney diseases. The Structure and Function of Podocytes Podocytes possess a distinct structure that includes a cell body and long, foot-like processes known as pedicels. ...
A New Drug to Reduce Heart Attacks and Strokes The newly approved drug Sotagliflozin (Inpefa) has shown promise in reducing heart attacks and strokes among patients with type 2 diabetes and chronic kidney disease. It works as a dual SGLT1 and SGLT2 inhibitor, helping to regulate blood sugar levels while also protecting the heart. ...
Glycated collagen mainly exists in various tissues in the human body, especially those rich in collagen, such as skin, bones, joints, blood vessels, and other connective tissues.Under normal physiological conditions, glycation occurs as a natural biochemical process, but its degree is usually low. In certain disease states, especially in patients with diabetes, the production of ...
Understanding Sleep Apnea and Its Types Sleep apnea is a sleep-related breathing disorder that results in poor sleep quality and can lead to daytime fatigue or sleepiness, forgetfulness, and irritability. According to the Mayo Clinic, there are 3 types of sleep apnea to be aware of as follows: OSA or obstructive sleep apnea is the more common form of the disorder and affects roughly 30% of ...
MMPs are involved in pathological processes such as hypertension, eclampsia, vascular inflammation, atherosclerosis, coronary syndromes and myocardial infarction, cerebral ischemia and ischemic stroke, peripheral arterial disease, aneurysms, chronic venous disease, etc. MMPs can be used as biomarkers and potential therapeutic targets for certain vascular ...
Limitations of siRNA as a proprietary drug Naked siRNA is easily degraded by nucleases in blood, and its relatively high molecular weight, negative charge, and hydrophilicity make it difficult to penetrate cell membranes. siRNA tends to accumulate in the kidney and be excreted in urine or is captured by the reticuloendothelial system (RES), thus cannot effectively bind to target ...
Osteoporosis is a type of disease that is difficult to cure. According to the etiology, it can be divided into primary osteoporosis, secondary osteoporosis and idiopathic osteoporosis. ...
Diabetes is a chronic disease that affects more than 540 million people worldwide and is one of the leading causes of death and disability worldwide. ...
GLP-1 agonists and SGLT-2 inhibitors in combination with or without metformin (as required for glycemic management) have also been recommended by multiple guidelines as appropriate initial treatment for type 2 diabetes patients with atherosclerotic cardiovascular disease (ASCVD) or those at high risk for ASCVD, heart failure and/or chronic kidney ...
These include: Atrial fibrillation (Afib) Coronary artery disease Diabetes High blood pressure (hypertension) Obstructive sleep apnea (OSA) Obesity Chronic kidney disease Amyloidosis or other infiltrative heart diseases What are the symptoms of diastolic heart failure? ...
This condition may be due age or might be due some chronic conditions like Diabetes mellitus (DM) or chronic kidney disease (CKD). Extreme muscle wasting often results in weight loss. Such a condition is generally referred to as cachexia, which is a complex metabolic syndrome that is associated with an underlying disease and characterized by ...
Dental Problems Linked To Heart Disease and Diabetes Over the last ten years there has been a growing body of evidence linking periodontal disease and systemic diseases. ...
Background: Synthetic expanded polytetrafluorethylene (ePTFE) grafts are routinely used for vascular repair and reconstruction but prone to sustained bacterial infections. Investigational bioengineered human acellular vessels (HAVs) have shown clinical success and may confer lower susceptibility to infection. Here we directly compared the susceptibility of ePTFE grafts and HAV to bacterial ...
Abstract : Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used to monitor flow rates and vascular diameters throughout the study. Intimal hyperplasia in the outflow vein of TEVGs was assessed at ...
Mice have long served as the species of interest for biomedical research thanks to their genetic, physiological, and anatomical similarity to humans. Mice kidney samples are used to study renal biology covering topics such as acute kidney injury to chronic kidney disease, both of which are extremely useful for better ...
Silence Therapeutics, a pioneer in the development of novel small interfering RNA (siRNA) therapeutics, and Mallinckrodt plc, a global biopharmaceutical company, announced the submission of a clinical trial application (CTA) for SLN501, a siRNA therapy targeting the complement C3 protein, on March 23, 2022. Silence will receive a $3 million milestone payment from Mallinckrodt as a result of the ...
In medicine, taking a holistic approach means treating the whole person - body, mind, spirit, and emotions - to achieve one’s optimal health and wellness. For example, if a patient comes in with a sharp, jabbing pain in his hand - a symptom of peripheral neuropathy - a holistic treatment plan may not only include pain relief medicine but also address underlying causes of pain. A holistic ...