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Metabolic Enzymes Articles & Analysis
21 articles found
Plant cell viability refers to the proportion of living, metabolically active cells in a given sample. It provides insight into cellular health, growth potential, and the effects of treatments such as cryopreservation, toxins, or genetic modification. ...
This process is primarily managed by two opposing families of enzymes: histone acetyltransferases (HATs), which add the acetyl group, and histone deacetylases (HDACs), which remove it. ...
S9 metabolic stability assays provide critical insights into how a compound behaves within biological systems, especially concerning its metabolism, stability, and overall pharmacokinetics. ...
Introduction Cytochrome P450 (CYP) refers to a family of enzymes that play a fundamental role in the metabolism of various substances within the body, particularly drugs, toxins, and endogenous compounds. ...
ADME stands for Absorption, Distribution, Metabolism, and Excretion, which are critical processes that determine the fate of a drug within the body. ...
Invertase, also known as β-fructofuranosidase, is a crucial enzyme in the field of biochemistry and food science, primarily recognized for its ability to catalyze the hydrolysis of sucrose into glucose and fructose. ...
Pharmacokinetic characteristics are composed of and determined by drug absorption, distribution, metabolism and excretion. The structure, physiological properties and pharmacokinetic characteristics of monoclonal antibodies are different from those of traditional small molecule drugs. ...
This process is catalyzed by glycosyltransferases, enzymes that transfer the sugar molecule from the nucleotide sugar to a growing glycan chain. ...
Many abnormal physiological states are associated with disorders of lipid metabolism. Studying the changes of lipids in different states of the organism at the systemic level can help analyze the mechanisms of lipid metabolic networks. Identification of key lipids and related enzymes can help to identify potential abnormalities in ...
Influencing the activity of sugar metabolism enzymes, promoting glycogen synthesis, or inhibiting glycogen breakdown. ...
Before reaching NT5E, adenosine triphosphate (ATP) undergoes a two-step hydrolysis process, transforming into AMP thanks to the enzyme ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1), also known as CD39. ...
Her team's imaging shows how the metabolism of the mouse brain changes when glycolysis is blocked in neurons. "This neuroimaging approach provides unprecedented information on brain metabolism," Chaumeil said. "The promise of metabolic imaging to inform basic biology and improve clinical care is enormous; there is still much to be explored." ...
Enzymes are specific to reactions, and specific enzymes can catalyze specific chemical reactions. ...
Enzymes control the entire body, and when enzymes function abnormally is fatal to human. ...
With the progress of research, the effects of CYP450 on organic synthesis and drug metabolism have been gradually explored. CYP enzymes can be classified according to the membrane-bound and soluble forms. ...
Fatty acids, along with glucose and amino acids, are the main source of energy for cell growth and proliferation. Abnormalities in fatty acid metabolism are commonly seen in cancer. A growing number of studies have shown that increased ab initio synthesis of fatty acids in tumor cells is a prominent feature in the development of cancer. ...
In humans and mammals, alcohol dehydrogenase and aldehyde dehydrogenase (ALDH) constitute the alcohol dehydrogenase system, which is involved in ethanol metabolism in vivo and is an important metabolic enzyme in humans and animals. As a key enzyme in the metabolism of major short-chain alcohols in organisms, it ...
Excess omega-6 fatty acids can interfere with the health benefits of omega-3 fatty acids because they compete for the same rate-limiting enzymes. An excessive omega-6:omega-3 ratio shifts the physiological state of tissues towards the pathogenesis of many diseases, such as blood clots, inflammation, etc. ...
Enzymes are specific to reactions, and specific enzymes can catalyze specific chemical reactions. ...
The potential new medicines are for the treatment of methylmalonic acidemia (MMA) and propionic acidemia (PA), diseases with defective enzymes along the same metabolic pathway. These diseases are caused by a genetic defect that results in either too little or no production of a critical metabolic enzyme produced by liver cells, ...