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While the dangers of primary smoking are well-known, nearly half of the U.S. population remains at risk from the silent threat of secondhand smoke (SHS). Chronic exposure to SHS triggers a cascade of inflammation and vascular damage that can lead to irreversible conditions like COPD and emphysema. A recent study from Sturgis et al. (2025) has demonstrated a promising new therapeutic candidate: ...
l Staining time and concentration: Overstaining can mask real differences in viability. l Microscopy and imaging: Use consistent settings for fluorescence or absorbance measurements. ...
Precise and safe delivery of drugs to target sites has always been an important task for researchers in modern medicine. With the development of nanotechnology, a variety of nanodrug delivery systems (NDDS) have been designed and prepared, such as the most familiar liposomes, polymer nanoparticles, and metal nanoparticles. However, a new kind of drug delivery system has also gradually emerged in ...
Introduction The BALB/C mouse is a widely used inbred strain in biomedical research, particularly in the fields of immunology, cancer research, and genetics. Among the various tissues studied, the kidney holds significant importance due to its complex structure and multifaceted role in physiological functions. A formalin-fixed paraffin-embedded (FFPE) block of the BALB/C mouse kidney serves as an ...
High-resolution techniques, such as X-ray crystallography and cryo-electron microscopy, have enabled researchers to visualize the interactions between antibodies and their antigens. ...
The utilization of bright field microscopy allows for clear visualization of traditional ISH, where localization of nucleic acids within various biological samples can be achieved with remarkable clarity. ...
Histological image analysis has emerged as a pivotal domain in biomedical research and clinical diagnostics, allowing scientists and healthcare professionals to decipher the intricate structures of tissues at a microscopic level. This analysis encompasses the examination of biological tissues to understand their composition, organization, and pathology, which can be crucial for diagnosing ...
The final stages include morphological analysis through scanning electron microscopy, which ensures surface uniformity, and disintegration testing in simulated saliva to evaluate drug release profiles. ...
Cancer is a worldwide disease and one of the leading causes of morbidity and mortality today. Traditionally, mouse models have been used for research as in vivo model organisms. However, the zebrafish (Danio rerio), also known as zebrafish, has emerged as an important new cancer model due to its small size, brood weight, and rapid maturation time, complements models that can traditionally be ...
Tissue Sections and Immunofluorescence StainingUsing specific anti-collagen antibodies to stain tissue sections, and then observing with a fluorescence microscope, collagen can be located and quantified at the tissue level.2. Confocal Microscopy or Electron MicroscopyThese higher resolution imaging techniques can be used to observe the distribution and structure of collagen at ...
Cytoskeleton Technologies ·High-Resolution Microscopy The development of advanced microscopy techniques, such as super-resolution microscopy (e.g., STORM, PALM), has drastically improved our ability to visualize the cytoskeleton. ...
Structural biology techniques, such as X-ray crystallography and cryo-electron microscopy, are providing unprecedented insights into RNase function and guiding the rational design of modified enzymes. ...
Currently, DNA constructs encoding fluorescent proteins fused to LC3 are widely employed for introduction into cells for monitoring autophagosome formation by fluorescence microscopy. QVirus™ Platform has launched series of lentiviral packaging service of autophagy related biosensors, in which GFP and/or RFP tags are fused at the C-termini of the autophagosome marker LC3, ...
Despite the abundant content of collagen, accounting for about 30% of total body protein, it may be difficult to purify and analyze. This is due to collagen molecules forming an extensive network through different types of cross-linking, making the collagen molecules insoluble and difficult to extract.At present, several types of analysis methods are available for collagen analysis:ELISA of ...
Introduction to Variant Analysis Rare DNA changes within a population of cells are the first manifestations of mutations, which are the fuel for evolution. The research of genomic variation between species and individual organisms has been revolutionized by next-generation sequencing (NGS) technologies. Variant detection and analysis refer to the sequencing and difference analysis of a genome ...
Techniques like dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) are used to analyze the size, shape, and surface properties of the nanoparticles. ...
Simultaneously, advancements in structural biology, including X-ray crystallography and cryo-electron microscopy, provide unprecedented insights into the three-dimensional structures of target proteins and their interactions with potential drug molecules. ...
One such assay is the fluorescent microscopy-based analysis of cell nuclei and mitochondria, where apoptotic cells exhibit condensed and fragmented nuclei, along with altered mitochondrial membrane potential. ...
Cancer is a complex disease that involves a delicate interplay between the tumor cells and the host immune system. Cytokines play a critical role in this interplay, mediating the communication between different cells of the immune system and modulating immune responses. As such, cytokine profiling is becoming increasingly important in the study of cancer and is being used to support research, ...
Cancer is a complex disease that involves a delicate interplay between the tumor cells and the host immune system. Cytokines play a critical role in this interplay, mediating the communication between different cells of the immune system and modulating immune responses. As such, cytokine profiling is becoming increasingly important in the study of cancer and is being used to support research, ...