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Neuropathy Articles & Analysis
30 articles found
Lipids are not merely structural components of cellular membranes—they also act as powerful signaling molecules that orchestrate key physiological processes. Among the enzymes regulating lipid signaling, ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2), also known as autotaxin, plays a central role by converting lysophosphatidylcholine (LPC) into the bioactive lipid ...
One such disease is Charcot-Marie-Tooth disease type 2A (CMT2A), a hereditary peripheral neuropathy characterized by progressive muscle weakness and sensory loss. ...
Hyperglycemia and insulin resistance can promote autonomic neuropathy, contributing to cardiac stiffness, hypertrophy, and fibrosis. [41] Sex Differences The higher occurrence of HFpEF in women suggests that sex-dependent mechanisms may be involved in HFpEF pathogenesis (Dunlay et al., 2017).[41] In general, women tend to show more concentric LV remodeling, with smaller LV ...
Patients are contraindicated if they have been assessed to have bilateral carotid bifurcations located above the level of the mandible, baroreflex failure or autonomic neuropathy, uncontrolled symptomatic cardiac bradyarrhythmias, carotid atherosclerosis that is determined by ultrasound or angiographic evaluation greater than 50%, ulcerative plaques in the carotid artery as ...
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(2) Safety and Tolerability Compared with bortezomib, carfilzomib had less peripheral neuropathy. In RRMM patients, the rate of grade 3 peripheral neuropathy was 1.3%, but no patients had grade 4 events, and only 1% of patients required dose adjustment or Withdrawal. ...
Insulin dependent diabetic, peripheral neuropathy, hypertension, renal failure on hemodialysis; history of chronic foot ...
Non-insulin dependent diabetes, venous insufficiency, peripheral neuropathy, HTN, CHF, COPD, ...
Subject: 68/female. Diabetes, peripheral neuropathy, and venous insufficiency. Necrotic tissue was treated with moistened MIRRAGEN™ advanced wound matrix for 2 days to soften and loosen necrotic tissue for easy ...
What is diabetic neuropathy? The most common complication of diabetes is neuropathy, which is nerve damagecaused by high blood sugar. Most neuropathy affects the legs, hands and feet and usually presents as numbness, pain or tingling. ...
Long non-coding RNAs (lncRNAs) are a class of RNAs that do not code for proteins and are typically greater than 200 nucleotides in length. Studies have shown that lncRNAs are quite complex in function and play an important role in various biological processes such as development, differentiation, proliferation, metastasis, apoptosis, stem cell pluripotency, and DNA damage. Therefore, those ...
The Limits of Stability (LOS) is perhaps the most used protocol in the literature for balance assessment in a dynamic task. It quantifies the ability to intentionally displace the center of gravity to the patient’s stability limits without losing balance. This protocol provides information regarding voluntary motor control, which also helps screening fall risk in elderly people [1]. How ...
Humans are inherently social beings who thrive on making and maintaining social relationships. Connecting with and supporting one another forms deep bonds that make us feel seen, valued, and like we belong. These social interactions are not only important for our emotional well-being but also for our physical well-being-maybe even more so than originally thought. Loneliness, an increasingly ...
INTRODUCTION After a peripheral nerve injury, fast conducting large myelinated afferent A-bcta fiber transmission diminishes over time. On the other hand, firing of smaller pain transmitting fibers such as A-dclta and C-fibcrs is enhanced. This aberrant afferent neuronal behavior is thought to be one of the main neuronal mechanisms leading to development of chronic posttraumatic peripheral ...
Abstract Background. Peripheral nerve injury can result in the formation of neuroma/nerve entrapment, a persistent peripheral neuropathic pain state which is often refractory to invasive interventions or medications. Therefore, there is a need in the field of pain management to develop innovative noninvasive therapy in treating post-traumatic peripheral neuropathic pain states. A new ...
For example, if a patient comes in with a sharp, jabbing pain in his hand - a symptom of peripheral neuropathy - a holistic treatment plan may not only include pain relief medicine but also address underlying causes of pain. ...
Christine Salcher, DPM Sherman, Texas and Amyee McAlister, Healthline Patient: 50-year-old Caucasian female with a pressure ulcer that has progressively gotten larger, deeper, more malodorous, fibrotic, and necrotic Comorbidities: Diabetes, diabetic retinopathy & peripheral neuropathy Age of Wound: 90 days Days on Service: 55 days Outcome: Goals met. ...
Severely high blood sugar levels and long-term burnout that leads to long-term high blood sugars can increase your risk for many of the diabetes complications you’ve been warned about, such as neuropathy, retinopathy, nephropathy, and slow wound healing. Bottom line, diabetes is a chronic and demanding disease. ...
However, over time, many patients still develop complications, including cardiovascular disease, retinopathy, neuropathy, and nephropathy. T1D goes through several stages before the onset and the clinical diagnosis is obtained. ...
However, Adcetris, when used alone, caused potentially severe peripheral neuropathy, neutropenia, and thrombocytopenia, all of which are typical side effects of antiplatelet drugs. ...
These reasons are given in order from the most to least common: Sleeping in a bad position Carpal tunnel syndrome Cubital tunnel syndrome Peripheral neuropathy (diabetes and alcohol abuse) Cervical Spondylosis Raynaud's disease Vascular diseases Stroke Multiple sclerosis Medication Side Effects (Chemotherapy) Vitamin B12 Deficiency Numb finger numbness due to ...