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Bowel Cancer Articles & Analysis

9 news found

Carina Biotech raises $7.5 million at first close with Tenmile as the cornerstone investor

Carina Biotech raises $7.5 million at first close with Tenmile as the cornerstone investor

The capital raise enables Carina to complete its Investigational New Drug (IND) enabling studies and initiate a CAR-T clinical trial of our LGR5 CAR-T cell for patients with advanced colorectal (bowel) cancer. “Colorectal cancer is Australia’s second deadliest cancer and its incidence is rising in people under the ...

ByCarina Biotech


Carina Biotech appoints Cell Therapies to undertake manufacture of LGR5 CAR-T cells for clinical trial

Carina Biotech appoints Cell Therapies to undertake manufacture of LGR5 CAR-T cells for clinical trial

Highlights Melbourne-based contract development and manufacturing organisation Cell Therapies will manufacture Carina Biotech’s LGR5 CAR-T cells for a first-in-human clinical trial for patients with advanced colorectal (bowel) cancer. Carina’s CAR-T cells are targeted at LGR5, a cancer stem cell marker that is highly expressed ...

ByCarina Biotech


Carina Biotech submits LGR5 CAR-T pre-IND (Investigational New Drug) package to the US Food & Drug Administration

Carina Biotech submits LGR5 CAR-T pre-IND (Investigational New Drug) package to the US Food & Drug Administration

Carina Biotech is very pleased to announce that we have submitted a pre-IND (Investigational New Drug) application to the US FDA (Food & Drug Administration) for our CAR-T therapy that targets a cancer stem cell antigen known as LGR5. This represents a major step towards taking our CAR-T cell (CNA3103) into a Phase I/IIa clinical trial in patients with advanced colorectal ...

ByCarina Biotech


Versius introduced in leading public hospitals in Egypt

Versius introduced in leading public hospitals in Egypt

Versius is being used to perform a range of high-volume general surgery and urological procedures, helping to treat patients with colorectal and urological cancers, bowel and kidney disease. High tech surgical care is highly prominent in the health system in Egypt, with adoption of the latest technology for RAS growing rapidly in Ministry of Health supported ...

ByCMR Surgical Ltd


Manufacture of Carina’s LGR5 CAR-T has begun with CellVec contracted to produce GMP-grade lentivirus constructs

Manufacture of Carina’s LGR5 CAR-T has begun with CellVec contracted to produce GMP-grade lentivirus constructs

Singapore-based CellVec will manufacture clinical-grade lentivirus – the first critical step in making LGR5 CAR-T cells for a first-in-human clinical trial for patients with advanced colorectal (bowel) cancer in late 2022. Lentiviruses are widely used as a tool to deliver genes of interest to cells. In this case, the lentivirus transduces (or inserts) a ...

ByCarina Biotech


Carina Biotech raises $5.4 million to ready LGR5 CAR-T program for advanced colorectal cancer for the clinic

Carina Biotech raises $5.4 million to ready LGR5 CAR-T program for advanced colorectal cancer for the clinic

The funding will enable us to undertake the required studies to initiate a clinical trial of our lead LGR5-targeted CAR-T program for the treatment of advanced colorectal (bowel) cancer in late 2022. Dr Steve Burnell, CEO of Minderoo Foundation’s Collaborate Against Cancer Initiative, commented: “We are pleased to accelerate the ...

ByCarina Biotech


Proximie and Vodafone in successful 5G remotely assisted surgery trials

Proximie and Vodafone in successful 5G remotely assisted surgery trials

Proximie has teamed up with Vodafone to pilot the role of 5G in increasing the connectivity and performance of remote assistance and training in cancer care. Trial with the assistance of 5G in using Proxime to ‘scrub in’ clinicians is taking place at University Hospital of Wales and University Hospital Llandough. Trial will be used in the diagnosis and treatment of ...

ByProximie Limited


Edinburgh Molecular Imaging are part of a EPSRC funded consortium

Edinburgh Molecular Imaging are part of a EPSRC funded consortium

Edinburgh Molecular Imaging is part of an EPSRC funded consortium, led by Dr Jon Shephard of Heriot-Watt University in collaboration with Professor David Jayne from the University of Leeds to develop a revolutionary new bowel cancer surgery tool that will enable surgeons to carry out operations with far greater ...

ByEdinburgh Molecular Imaging


EM Imaging obtains global licence for optical agent that detects cancer early

EM Imaging obtains global licence for optical agent that detects cancer early

(EM Imaging) has signed an exclusive global license for a novel optical imaging agent that could improve the detection of early-stage colorectal (bowel) cancer. EM Imaging, a company which develops and commercialises novel optical imaging agents, recently signed the licensing agreement with GE Healthcare Ltd. and Dyax Inc. EM Imaging will now complete the ...

ByEdinburgh Molecular Imaging

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