Liver Transplant Articles & Analysis
15 news found
The published study provides a comprehensive analysis of the liver safety profile of AD04 compared to a placebo in individuals with AUD and a specific 5-marker genetic profile. AUD, characterized by compulsive alcohol consumption and loss of control over intake, poses significant health risks and is a major contributor to alcohol-associated liver disease (ALD), a ...
In addition, the likelihood of successfully developing the orphan drug is increased with the Agency's support when designing the drug development strategy. PSC is a chronic cholestatic liver disease that is caused by bile duct inflammation and fibrosis of unknown cause. The inflammation can stop the flow of bile acids and lead to liver fibrosis or ...
In the first two Part B cohorts, ALN-HSD was associated with robust target knockdown and numerically lower liver enzymes and biopsy-derived nonalcoholic fatty liver disease (NAFLD) Activity Score (NAS)* over six months in patients receiving ALN-HSD (N=20) relative to placebo (N=4). ...
First known bovine model used to demonstrate safety and efficacy in gene replacement therapy MSUD is a severe genetic disease with liver transplantation or dietary restriction as the only treatments currently available ASC Therapeutics in partnership with the UMass Chan Medical School and the Clinic for Special Children (CSC), presented safety and efficacy ...
Hepatic steatosis can progress to nonalcoholic steatohepatitis (NASH) with fibrosis, and NASH-associated liver failure is one of the leading causes of liver transplant in the United States. ...
New partnership agreement with Ophiomics (Portugal), initially focused on the commercialization of HepatoPredict™, a prognostic gene expression signature test to help identify which patients could benefit from curative-intent surgery, in particular liver transplantation. Continued ramp-up of the fully automated ML2 manufacturing line with the transfer of ...
In addition, Nature Scientific Reports published the company’s research analyzing gene expression at various stages of nonalcoholic fatty liver disease. NASH, one of the leading causes of transplantation, is a serious, chronic liver disease that is estimated to impact over 16 million people in the United States alone. NASH is characterized ...
The data were presented in a poster at The Liver Meeting® 2021, the annual meeting of the American Association for the Study of Liver Diseases (AASLD). “In people with AATLD, misfolded AAT aggregates in the liver and causes liver injury that may progress to liver fibrosis, cirrhosis and hepatocellular ...
Despite the current standard of care involving dietary control, carnitine supplementation and in more severe cases, organ transplantation, there remains a high unmet medical need in MMA and PA. As a small molecule, HST5040 has the ability to distribute to all affected tissues and thus has the potential to be active throughout the body, including the liver, ...
As a result of longer life expectancy and the incidence of major pathologies such as cancer and diabetes, the number of people waiting for an organ transplant is constantly increasing: at the end of 2016 in the EU member countries more than 142,000 patients were waiting for a kidney, liver, heart, lung, pancreatic or intestinal transplant ...
ByPoietis
Our new customer in Pakistan is one of the most reputed medical institutions in that part of Asia and they provide specialised medical care for patients suffering from kidney, liver, related cancer diseases and ethical transplant procedures. The unique philosophy of this hugely respected institution is that they believe no one should die because they cannot ...
Hepatitis C (HCV) infection is the most common cause of liver cell carcinoma and liver transplants in Europe, which are possible late–stage effects of a chronic infection, alongside cirrhosis of the liver. ...
Researchers at the University of Birmingham have published results that suggest a non-invasive breath test for liver disease using an IONICON PTR-MS. Elevated levels of limonene in patients have been found to be indicative of a diseased liver. ...
The liver is unique among organs in its ability to regenerate after being damaged. ...
The Phase 2 trial involves treatment of patients with advanced, primary liver cancer refractory to standard therapies. Patients are randomized to receive treatment at one of two dose levels. ...