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G Protein Coupled Receptor Equipment & Supplies In Saskatchewan
49 equipment items found
Manufactured by:Confo Therapeutics based inGhent/Zwijnaarde, BELGIUM
G protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in the body. They play a key role in a broad range of biological processes by binding to a wide variety of signaling molecules, yet they share a common architecture. GPCRs are comprised of seven transmembrane (TM) helices that span the cell membrane and intervening loops that are presented towards ...
Manufactured by:Creative Peptides based inNew York, NEW YORK (USA)
Calcitonin (salmon) is a 32-amino acid polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C-cells) of the thyroid, and in many other animals in the ultimobranchial body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). The calcitonin receptor has been cloned and shown to be a member of the ...
Manufactured by:Systasy Bioscience GmbH based inMunich, GERMANY
The proprietary splitSENSOR technology is a highly sensitive,flexible and easy-to-use reporter assay system to monitor various cellular events in living cells, including the activity of drug targets. Various cellular events, such as regulated protein-protein interactions, can be robustly and quantitatively measured both at the membrane and in the cytosol of the cell. This feature makes it, for ...
Manufactured by:Confo Therapeutics based inGhent/Zwijnaarde, BELGIUM
Confo Therapeutics is building a pipeline of drug candidates with the potential to transform therapeutic outcomes for patients with severe illnesses lacking disease-modifying ...
Manufactured by:BCN Peptides S.A. based inSant Quintí de Mediona, SPAIN
Abaloparatide is 34 amino acid synthetic analog of parathyroid hormone-related protein (PTHrP) (1-34). It works as an anabolic agent for the bone, through selective activation of the parathyroid hormone 1 receptor (PTH1R), a G protein-coupled receptor (GPCR) expressed in the osteoblasts and osteocytes. ...
Manufactured by:Kiadis Pharma NV based inAmsterdam, NETHERLANDS
Accessing a new repertoire of targets. Two classes of molecule with therapeutic potential that are not currently addressed by antibody drugs are G-protein-coupled receptors and ion channels, largely because they display small epitopes not accessible to traditional antibodies and their sequence is often conserved and thus less likely to be ...
Manufactured by:Echelon Biosciences, Inc (EBI) based inSalt Lake City, UTAH (USA)
(2S)-Oleyl LPA is an analog of 18:1 LPA in which the fatty ester bond to gycerol has been replaced by a metabolically stable ether linkage. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several ...
Manufactured by:Protein Foundry LLC. based inWest Allis, WISCONSIN (USA)
Human CXCL2 is a 73 amino acid, ELR+ chemokine that belongs to the GRO isoform subset which activates the G protein-coupled receptors CXCR2. LPS-stimulated macrophages strongly express CXCL2 in addition to the constitutive expression by macrophages. CXCL1 is a potent chemoattractant for neutrophils and hematopoietic stem cells and an activator of basophils. ...
by:Orion Biotechnology Canada, Ltd. based inOttawa, SWITZERLAND
G Protein-Coupled Receptors (GPCRs) are involved in a wide range of physiological and pathological processes and represent a large class of drug targets accounting for >30% of all drugs on the market. These drugs, however, only cover 15% of the entire GPCR family, and many valuable receptors remain undrugged. In particular, GPCRs whose natural ligands are large peptides or small proteins are ...
Manufactured by:Addex Therapeutics based inGeneva, SWITZERLAND
Allosteric modulators are an emerging class of orally available small molecule therapeutic agents that may offer a competitive advantage over classical ...
Manufactured by:ProSpec-Tany TechnoGene Ltd. based inRehovot, ISRAEL
BCA 1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain topological domain containing 110 amino acids (23-109 a.a) and having a molecular mass of 12.7kDa. BCA 1 is fused to a 23 amino acid His-tag at N-terminus. SYNONYMS: C-X-C motif chemokine 13, Small-inducible cytokine B13, B lymphocyte chemoattractant, CXC chemokine BLC, CXCL13, BCA1, BCA-1, CXCL-13, B cell ...
by:AdAlta Limited based inBundoora, AUSTRALIA
An i-body is a human protein that belongs to the class of next generation antibodies. The i-body is built on the scaffold of a human protein and engineered with two loops that mimic the shape of shark antibodies. These loops are responsible for binding or interacting with a particular target (in circulation or on a cell) that is causing disease. i-bodies are identified and developed using our ...
Manufactured by:Mol Scientific based in, CHINA
Mol Scientific offer high-quality RFamide ligand for orphan G-protein-coupled receptor SP9155, P517 peptide product(MPE0005929). Mol Scientific committed to bring our esteemed customers high quality products and the finest services at highly competitive prices. ...
Manufactured by:Mol Scientific based in, CHINA
Mol Scientific offer high-quality RFamide ligand for orphan G-protein-coupled receptor SP9155, P52 peptide product(MPE0008281). Mol Scientific committed to bring our esteemed customers high quality products and the finest services at highly competitive prices. ...
Manufactured by:ProSpec-Tany TechnoGene Ltd. based inRehovot, ISRAEL
BCA-1/ BLC (CXCL13) Rhesus Macaque Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 87 amino acid and having a molecular mass of approximately 10.3kDa. SYNONYMS: C-X-C motif chemokine 13, Small-inducible cytokine B13, B lymphocyte chemoattractant, CXC chemokine BLC, CXCL13, BCA1, BCA-1, CXCL-13, B cell Attracting Chemokine-1, BLC, ANGIE, BLR1L, SCYB13, ...
Manufactured by:SYnAbs S.A. based inGosselies, BELGIUM
Transmembrane proteins are probably the most complex and challenging antigens to target with monoclonal antibodies. Indeed, despite their strong presence in the animal kingdom and their implications in many cellular mechanisms, they remain very difficult to access due to intrinsic properties. ...
Manufactured by:ProSpec-Tany TechnoGene Ltd. based inRehovot, ISRAEL
CXCL13 Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 87 amino acids and having a molecular mass of 10.3 kDa. The BCA-1 is purified by proprietary chromatographic techniques. ...
Manufactured by:Protein Foundry LLC. based inWest Allis, WISCONSIN (USA)
Human CXCL4, additionally known as Platelet-factor 4, is a 70 amino acid protein that is released by activated platelets to promote coagulation. CXCL4 binds to the G protein-coupled receptor CXCR3-B, found in kidney, heart and liver tissue, but a canonical signaling receptor is still unknown. CXCL4 readily binds to heparin-like molecules and glycoproteins and is a regulator of endothelial and ...
Manufactured by:Protein Foundry LLC. based inWest Allis, WISCONSIN (USA)
Human CCL5, also known as Regulated upon Activation, Normal T cell Expressed and presumably Secreted (RANTES), attracts and activates leukocytes and plays a primary role in the inflammatory immune response. CCL5 activates several G protein-coupled receptors including CCRs 1, 3, 4, and 5. CCL5 binding to CCR5 inhibits the infectivity of M-tropic HIV-1 strains. Proteolytic removal of the two ...
Manufactured by:InterAx Biotech AG based inVilligen, SWITZERLAND
Our breakthrough platform combines systems biology, pharmacology, and artificial intelligence to accelerate the hit-to-lead process in GPCR drug discovery. InterAx is setting an industry example of how to better understand the biology of a disease and de-risk drug candidates. Instead of only leveraging large quantities of data with machine learning algorithms, we simultaneously incorporate ...