Epithelix
Epithelix - Model SMALLAIR -In Vitro 3d Human Small Airway Epithelium
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SmallAir™ is an in vitro cell model of the human small airway epithelium cultured at the air liquid interface.
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We produce SmallAir™ with high standards of quality and reproducibility
- Reconstituted using primary small airways human cells
- Remains fully differentiated and functional for over one year in culture
- Ready and easy to use
- Cultured in chemically defined serum-free medium
- Available worldwide in 24 well format
SMALLAIR™ IS AVAILABLE FROM
Patients with several pathologies:
- Healthy
- COPD (Chronic Obstructive Pulmonary Disease)
- Asthma
- Cystic Fibrosis (Several mutations available)
- Smoker
SMALLAIR™ CHARACTERISTICS
- Air-liquid interface
- Production of mucus
- Active cilia-beating
- Active ion transport
- Tight junctions
- Metabolic activity
- Cytokines, chemokines, metalloproteinases release
EXPRESSION OF CC-10 PROTEIN IN MUCILAIR™ AND SMALLAIR™
CC-10 was detected by Western Blot. As expected, SmallAir™ contained few Muc5-Ac positive cells (goblet cells). In contrast, CC-10 was not detected in MucilAir™. Instead, Muc-5Ac was highly expressed in MucilAir™.