Oncogene Equipment & Supplies In Canada
87 equipment items found
Manufactured by:Daiichi Sankyo Company Limited based inTokyo, JAPAN
TURALIO (pexidartinib) is an oral small molecule that targets colony stimulating factor 1 receptor (CSF1R), KIT proto-oncogene receptor tyrosine kinase (KIT), and FMS-like tyrosine kinase 3 (FLT3) harboring an internal tandem duplication (ITD) ...
Manufactured by:ACROBiosystems based inNewark, DELAWARE (USA)
Name:Receptor protein-tyrosine kinase erbB-2. Target Synonym:EC 2.7.10.1,HER-2/Neu,Herstatin,HER-2,TKR1,Receptor, ErbB-2,V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog,V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2,Neuroblastoma/Glioblastoma Derived Oncogene Homolog,C-Erb B2/Neu Protein,CD340 Antigen,EC:2.7.10.1,EC 2.7.10,MLN ...
Manufactured by:BridgeBio Pharma, Inc. based inPalo Alto, CALIFORNIA (USA)
RAS is one of the most well-known oncogenic drivers, with approximately 30% of all cancers being driven by RAS mutations, including large proportions of lung, colorectal and pancreatic tumors. BridgeBio’s approach to RAS cancers encompasses multiple “shots on goal” that target both KRAS mutant tumors and those in which RAS activates PI3Ka. We believe two of our approaches have ...
by:Sorrento Therapeutics, Inc. based inSan Diego, CALIFORNIA (USA)
Sorrento’s proprietary G-MAB technology, invented by Dr. Ji, is based on the use of RNA transcription for amplification of the antibody variable domains from over 600 donors. In-depth analysis of deep sequencing DNA data showed that the G-MAB library contains more than 10 quadrillion (1016) distinct antibody sequences. This makes it one of the largest fully human antibody libraries in the ...
Manufactured by:AccuGenomics, Inc. based inWilmington, NORTH CAROLINA (USA)
Accukit™ ONCO1LB contains a blend of 13 synthetic DNA internal standards (IS) to clinically actionable oncogenic regions of the genome (Table 1). The mixtures are physically and enzymatically fragmented to an average size of ~165bp and are suitable for use as routine spike-in controls for cell-free DNA assays. Accukit Onco1LB internal standards are spiked into each specimen prior to library ...
Manufactured by:ViruSure GmbH based inVienna, AUSTRIA
Gene therapy has brought hope to many diseases with unmet clinical need. The potential to permanently cure the patient through replacement of a defective gene with a healthy gene underscores the surge of interest in this exciting biopharma ...
Manufactured by:The Menarini Group based inFlorence, ITALY
NEXPOVIO is a first-in-class, oral exportin 1 (XPO1) inhibitor. XPO1 is a nuclear exporter protein that transport from the nucleus to the cytoplasm several proteins, including tumor suppressors, oncogenes, and proteins involved in governing cell growth; it is often overexpressed, and its function mis-regulated in several types of cancers. By inhibiting the XPO1 protein, tumor suppressors proteins ...
Manufactured by:Isarna Therapeutics GmbH based inMunich, GERMANY
Transforming growth factor beta (TGF-β) plays an important role in key biological processes such as cell proliferation, cell differentiation, immune response and tissue modeling. Because TGF-β is chronically elevated in many diseases, including ophthalmic and fibrotic diseases and cancer, and involved in their pathophysiology, it is an extremely versatile drug target throughout the ...
Manufactured by:Celemics, Inc. based inSeoul, SOUTH KOREA
Celemics’ Oncorisk Panel is specifically designed to analyze hereditary cancer associated genes. The OncoRisk Panel targets 31 well-known oncogenes, leading to a reduction of totalsequencing cost compared to whole genome sequencing or whole exome sequencing. Additionally, if the gene of interest does not exist on the panel, it can be added separatelythrough our gene add-on service. This ...
Manufactured by:StressMarq Biosciences Inc. based inVictoria, BRITISH COLUMBIA (CANADA)
Product Name: c-Met Antibody (pTyr1234). Description: Rabbit Anti-Human c-Met (pTyr1234) Polyclonal. Species Reactivity: Human, Mouse, Rat. Applications: WB. Antibody Dilution: WB (1:250-1:1000); optimal dilutions for assays should be determined by the user. Host Species: Rabbit. Immunogen Species: Human. Immunogen: Synthetic phospho-peptide from human c-Met around the phosphorylation site of ...
Manufactured by:TxinnoBioscience Inc. based inYongin-si, SOUTH KOREA
RAS GTPase family has 3 members encoding KRAS, HRAS and NRAS proteins which are involved in controlling normal growth signal. RAS GTPases are also well-known oncogenes that drive tumorigenesis when mutation is ...
Manufactured by:StressMarq Biosciences Inc. based inVictoria, BRITISH COLUMBIA (CANADA)
Product Name: c-Met Antibody (pTyr1349). Description: Rabbit Anti-Human c-Met (pTyr1349) Polyclonal. Species Reactivity: Human, Mouse, Rat. Applications: WB. Antibody Dilution: WB (1:250-1:1000); optimal dilutions for assays should be determined by the user. Host Species: Rabbit. Immunogen Species: Human. Immunogen: Synthetic phospho-peptide from human c-Met around the phosphorylation site of ...
Manufactured by:Caprico Biotechnologies, Inc. (CBI) based inNorcross, GEORGIA (US) (USA)
EAPII (also called TTRAP, TDP2) originally was identified as an interacting partner of oncogene ETS1, a founding member of ets transcription factor, and the cytoplasmic domain of CD40, a member of the tumor necrosis factor (TNF) receptor family. EAPII significantly represses ETS1 transcriptional activity and the synergistic transactivation by ETS1 and AP-1 or by ETS1 and NFκB. EAPII/TTRAP ...
by:Sumitomo Pharma Oncology, Inc. based inCambridge, MASSACHUSETTS (USA)
TP-1287 is an investigational oral CDK9 inhibitor that has shown favorable oral bioavailability in preclinical models. TP-1287 is enzymatically cleaved, yielding the active moiety, a potent inhibitor of CDK9.35 Inhibiting CDK9 is thought to downregulate the transcription of target genes, including MCL-1, reducing leukemic blast viability in MCL-1–dependent hematologic malignancies, and ...
Manufactured by:SEngine Precision Medicine based inSeattle, WASHINGTON (USA)
Guiding drug discovery with proprietary high throughput 3D patient cell technology and genomics will drastically increase the success of novel drug candidates and directly result in faster development at reduced costs. SEngine Precision Medicine’s innovative approach brings diagnostics, drug discovery and proprietary algorithms together with our patient-derived 3D tumor organoids to ...
Manufactured by:LGC SeraCare based inMilford, MASSACHUSETTS (USA)
The Seraseq Tumor Mutation DNA Mix v2 (AF7) HC is a multiplexed mixture of actionable biosynthetic DNA targets precisely blended with a single, well-characterized genomic background. This product is produced under rigorous design control and manufacturing practices to an allelic frequency of 7%, and is offered in a high concentration (HC) format at 25 ng/µL. Designed to assess the overall ...
Manufactured by:Tempus based inChicago, ILLINOIS (USA)
Tempus xE (version 2) is a whole exome next-generation sequencing assay that analyzes the entire coding region (exome) of the patient’s genome, combined with whole transcriptome RNA sequencing. Clinical sequencing is performed to 500x depth of coverage for tumor specimens and 150x for normal specimens for the clinically enhanced regions (648 genes). Non-enhanced regions are performed at ...
Manufactured by:MorphoSys AG based inPlanegg, GERMANY
Tulmimetostat is a second-generation EZH2 inhibitor that has been designed to achieve comprehensive target coverage through extended on-target residence time. EZH2 acts as an epigenetic writer and normally places one or more methyl groups on a histone protein, leading to the suppression of gene expression. Some cancers depend on an abnormal pattern of gene expression and re-direct EZH2 to genes ...
by:Xiamen Spacegen Co., Ltd. based inxiamen, CHINA
Detection Gene:K-ras (covering 21 loci related to targeted drugs). Detection Significance:Guiding the selection of KRAS G12C inhibitor , anti-EGFR and ...
Manufactured by:Virasoft Inc. based inSarıyer, TURKEY
The HER2 gene is an oncogene encoding the “Epidermal Growth Factor Receptor 2” which is a transmembrane glycoprotein. Amplification of the HER2 gene and overexpression of HER2 receptor on the cell membrane is observed in approximately %15 of invasive breast ...