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Immune Checkpoint Equipment Supplied In Asia Middle East
10 equipment items found
Manufactured by:Elpiscience based inShanghai, CHINA
LAG3 is an immune checkpoint receptor known to suppress T cell activation. We designed ES005 to block LAG3 ligands, including MHC class II and FGL1. Through unique epitope binding, ES005 is able to recognize human LAG3 with high affinity. In preclinical studies, ES005 inhibited tumor growth both as a monotherapy and in combination with a PD-1 ...
Manufactured by:Promega Corporation based inMadison, WISCONSIN (USA)
The antibodies used to stimulate T cell activation via interaction with co-stimulatory receptors on the effector cells can be cross-linked via binding to FcγRIIb receptors on CHO-K1 cells. Based on the properties of the antibody tested, the Co-Stimulatory Immune Checkpoint (i.e., OX40, CD40, GITR and 4-1BB) bioassays can be conducted in a single ...
Manufactured by:Promega Corporation based inMadison, WISCONSIN (USA)
4-1BB (CD137/TNFRSF9), a member of the tumor necrosis factor receptor superfamily, is an inducible co-stimulatory receptor expressed on T cells, natural killer (NK) cells and innate immune cell populations. When present on the cell surface, 4-1BB interacts with 4-1BB ligand (4-1BBL) and induces subsequent cell proliferation and production of interferon gamma (IFNγ) and interleukin-2 (IL-2), ...
Manufactured by:PharmAbcine Inc. based inYuseong-gu, SOUTH KOREA
PMC-309 is an engineered monoclonal antibody that targets the negative immune checkpoint human VISTA (V-domain Ig suppressor of T cell activation). It indirectly promotes T cells' immune responses by inhibiting VISTA-expressing immunosuppressive cells such as MDSCs (Myeloid-Derived Suppressor Cells) which suppress T cell inactivation and ...
Manufactured by:Elpiscience based inShanghai, CHINA
It has a unique mechanism of action as 4-1BB activation is dependent on PD-L1 binding. 4-1BB is a T cell co-stimulatory receptor and is a compelling immune checkpoint target. 4-1BB targeting antibodies being developed by multinational companies have exhibited dose-dependent liver toxicity in clinical trials, thereby limiting dose-escalation and ultimately their ...
Manufactured by:Eutilex Co.,Ltd. based inSeoul, SOUTH KOREA
Fully humanized anti-human 4-1BB monoclonal antibody. Agonistic effect of EU101 promotes cytotoxic T lymphocyte response and it leads to eradication of ...
Manufactured by:Jubilant Therapeutics Inc. based inBedminster, NEW JERSEY (USA)
Strong scientific and clinical rationale for novel small molecule PD-L1 ...
by:Xiamen Spacegen Co., Ltd. based inxiamen, CHINA
Detection Gene:KRAS,BRAF,NRAS,PIK3CA,TP53,DYPD,ERBB2,UGT1A1 and MSI（8 genes +MSI）. Detection Significance:Guiding individualized diagnosis and treatment of colorectal ...
by:Xiamen Spacegen Co., Ltd. based inxiamen, CHINA
Using high-throughput sequencing to test the coding regions and exon-intron junctions of five genes (MLH1, PMS2, MSH2, MSH6, EPCAM) in the germline panel, and the same five genes plus the BRAF V600E mutation in the tissue-based panel. Detection Gene:MMR-related genes MLH1, MSH2, MSH6, PMS2 and EPCAM, BRAF gene V600E mutation. Detection Significance:Germline test as confirmed diagnosis of Lynch ...
Manufactured by:Lineage Cell Therapeutics, Inc. based inCarlsbad, CALIFORNIA (USA)
VAC2 is an allogeneic, or non-patient specific, cancer vaccine candidate designed to stimulate patient immune responses to telomerase which is commonly expressed in cancerous cells but not in normal adult cells. VAC2, which is produced from our pluripotent cell technology using a directed differentiation method, is comprised of a population of mature dendritic cells. As the most potent type ...