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Regulators Of Immunity Equipment Supplied In Europe
10 equipment items found
by:Horizon Therapeutics plc based inSaint Kevin`s, IRELAND
Collaboration and option agreement with Q32 Bio to develop ADX-914, a fully human anti-IL-7Rα antibody that re-regulates adaptive immune function by blocking signaling mediated by both IL-7 and TSLP, two key immune ...
Manufactured by:OSE Immunotherapeutics based inNantes, FRANCE
A humanized monoclonal antibody, is an antagonist of the alpha chain of the interleukine-7 receptor, CD127, present on T effector cells, thus down regulating the immune activity. Interleukin-7 (IL-7) is a cytokine that controls the proliferation, apoptosis and activation of CD4 and CD8 effector T-cells in ...
Manufactured by:Virasoft Inc. based inSarıyer, TURKEY
But PD-L1 can be expressed by tumor cells and tumor stroma. Interaction tumoral PD-L1 with PD-1 stimulates PD-1-mediated T cell inhibition and down regulation of immune response. PD-L1-PD-1 pathway has proven value as a therapeutic target in a large number of malignancies including non-small cell lung cancer [2]. Immunohistochemical staining is a standardized ...
Manufactured by:OSE Immunotherapeutics based inNantes, FRANCE
a monoclonal antibody fragment and CD28 antagonist, selectively blunts CD28 co-stimulation while sparing the CTLA-4 co-inhibitory signal. The net effect of CD28 antagonism is down regulating effector T-cells while promoting T-Reg activity. The CD28/CTLA-4 pathway controls both T-cell activation and regulatory T-cell down regulation. CD28 receptor is expressed on ...
Manufactured by:Trenker Pharmaceutical Laboratories based inThines (Nivelles), BELGIUM
Vitamin D, D3, also know as "cholecalciferol" by scientists, is a fat-soluble vitamin with multiple functions. Well known among the general public as part of the process of bone mineralisation1 , it is also important in regulating immune function2, particularly in the differentiation and proliferation of hematopoietic cells3. In addition to a healthy, balanced ...
Manufactured by:MV BioTherapeutics SA based inBellinzona, SWITZERLAND
SNP-apyrase for oral use in the treatment of IBD • Lead compound, MV010, has shown animal PoC in a murine model of ulcerative colitis. • Abrogation of the pro-inflammatory function of extracellular ATP in the intestine without systemic immune suppression. • Amplification of secretory IgA production in Peyer's patches and gut-associated lymphoid tissue (GALT), ensuring high ...
Manufactured by:Kiadis Pharma NV based inAmsterdam, NETHERLANDS
Amlitelimab SAR445229 (formerly KY1005) is a human monoclonal antibody that targets OX40L, a key regulator of the immune system. Amlitelimab is designed to rebalance the immune system by blocking inappropriate activation and proliferation of ‘pro-inflammatory’ effector T cells and promoting expansion of ‘anti-inflammatory’ ...
Manufactured by:IMPACT International GmbH based inKoln, GERMANY
Autologous cell therapies make use of the natural endogenous mechanisms for the regeneration and healing of injured tissue. The body’s response to an injury is a complex healing cascade in order to heal the wound as quickly as possible. To understand how this regeneration process works, let us take a look into the cellular ...
Manufactured by:ProImmune Ltd. based inOxford, UNITED KINGDOM
CD1d Tetramers the world’s leading product for tracking NKT cells. Detect NKT Cells with CD1d Tetramers: ProImmune is the leading commercial source worldwide for fluorescently labeled human and mouse CD1d tetramers. CD1d-lipid complexes bind to T cell receptors of NKT cells of a particular specificity (as determined by the lipid ligand used), allowing identification and enumeration of ...
Manufactured by:Therawis based inMunich, GERMANY
Exosome-associated proteins are used to isolated microvesicles from biological fluids such as blood, urine or cerebral fluid and to identify the source of their origin. Example of such proteins are tetraspanins (CD9, CD63, CD81), immune regulation molecules (HLA-G, MHCI/II), membrane transport and fusion proteins (Rab5). Secretion of exosomes occurs by almost any ...