VelociHum is our immunodeficient mouse platform that can be used to accurately test human therapeutics against human immune cells and to study human tumor models. Through genetic humanizations, VelociHum mice have been optimized to allow for better development of human immune cells in vivo, as well as to allow for engraftment of primary ...

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Myeloid - In Vivo Myeloid Programming with mRNA

by:Myeloid Therapeutics based inCambridge, MASSACHUSETTS (USA)

Myeloid’s novel in vivo engineering platform specifically targets and activates myeloid cells to elicit broader anti-tumor adaptive immunity. Through this approach, Myeloid demonstrates that delivery of lipid-nanoparticles (LNPs) encapsulating mRNA results in uptake and selective expression by myeloid cells in vivo, leading ...

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Sigma-Aldrich HyStem - Model HYS020 - Cell Culture Scaffold Kit

Manufactured by:Sigma-Aldrich based inBellefonte, PENNSYLVANIA (USA)

Customizable and free of animal components, Hystem hydrogel cell culture scaffolds provide a complex, three dimensional environment in which cells are able to proliferate, much as they would in vivo. Customizable - each distinct cell type in a multicellular organism has its own unique microenvironment. Hystem offers the ...

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T-Cure - Receptor Therapy T Cell

Manufactured by:T-Cure BioScience, Inc. based inSherman Oaks, CALIFORNIA (USA)

T cell engineering with TCRs is a growing area of immuno-oncology with recent breakthroughs in clinical settings. The T-Cure approach involves identifying and isolating a high avidity TCR which specifically recognizes an intracellular or cell-surface target in solid tumors. This TCR is then typically introduced into a viral vector that can deliver the TCR into ...

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Emulate - Lung-Chip

Manufactured by:Emulate based inBoston, MASSACHUSETTS (USA)

Study lung physiology, disease, and the effect of drug candidates. A more human-relevant model for studying pulmonary physiology, with primary human cells in a lung-specific microenvironment. We are currently developing two distinct models of the human lung—the Alveolus Lung-Chip and the Airway Lung-Chip—to capture the specific tissue architecture and function of different lung ...

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Myeloid - Model MT-302 (TROP2-FcA LNP) - In Vivo Programming Pipeline

by:Myeloid Therapeutics based inCambridge, MASSACHUSETTS (USA)

Emerging from the Company’s proprietary ATAK™ CAR receptor library, Myeloid’s novel in vivo engineering platform specifically targets and activates myeloid cells to elicit broader anti-tumor adaptive immunity. Through this approach, Myeloid demonstrates that delivery of lipid-nanoparticles (LNPs) encapsulating mRNA results in uptake and ...

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4T1/firefly Luciferase (CMV) Stable Cells

Manufactured by:Cellomics Technology, LLC based inHalethorpe, MARYLAND (USA)

T4, a mouse mammary gland tumor cell line, has been widely used in cancer research and drug development in vitro and in vivo. 4T1/firefly luciferase (CMV) stable cells express transgenically firefly luciferase under the control of the CMV promoter. The proliferation and trafficing of the cells could be monitored in ...

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Celularity - Model CAR-T - Chimeric Antigen Receptor T Cells

Manufactured by:Celularity Inc. based inFlorham Park, NEW JERSEY (USA)

Chimeric Antigen Receptor T cells (CAR-T) are genetically engineered T cells that are modified to express an artificial T cell receptor on their surface that binds and targets cancer proteins in an HLA-independent ...

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BTX - Model Gemini - Twin Wave Electroporators System

Manufactured by:BTX - Harvard Bioscience, Inc. based inHolliston, MASSACHUSETTS (USA)

The Gemini Twin Wave Electroporators are flexible systems allowing both square wave and exponential decay wave electroporation in a single unit. Ideal for all of your electroporation needs, including CRISPR, in vivo, in vitro, in ovo and more. Systems for cuvettes or plates. These waveform combinations enable researchers to easily and efficiently electroporate eukaryotic and ...

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AgilePulse - Model Plus - Bipolar Transfection System

Manufactured by:BTX - Harvard Bioscience, Inc. based inHolliston, MASSACHUSETTS (USA)

Easily perform advanced transfection protocols with multiple groups of pulses—each with separate parameters. The AgilePulse™ PLUS Bipolar Transfection System is designed for efficient transfection of mammalian cells and tissues. This system is ideal for high efficiency transfection of mammalian cells, including difficult to transfect cell types, such as stem cells and primary cells. ...

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