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Montana Molecular - Borealis Arrestin Biosensors for Drug Discovery
The Borealis Arrestin Biosensors by Montana Molecular represent a cutting-edge tool in the realm of GPCR drug discovery, focusing on arrestin recruitment and signaling dynamics. These biosensors facilitate the continuous measurement of signaling activities in live cells, crucial for the development of precise pharmacological agents. The sensors are designed to work seamlessly with GraphPad Prism software, allowing for easy conversion of time course data into actionable insights. They offer robust Z' values in HEK293T cells and are supported by a plethora of receptor-specific kits for a wide range of GPCR pathways including Gs, Gi, Gq, and arrestin pathways. Additionally, these biosensors can be miniaturized to a 384-well format, supporting multiplexing with other sensors like cAMP, DAG, and Calcium, thereby providing comprehensive insights into the cellular signaling landscape critical for drug development.
Signaling dynamics is a new frontier in drug discovery, involving the design of drug molecules that signal for the right time in the right place. Biosensors, like the Borealis Arrestin Sensor, have been the foundation of the latest discoveries, enabling signaling dynamics to be recorded continuously over time in live cells.
Borealis, your best-in-class fluorescent biosensor for arrestin recruitment:
- Assess arrestin recruitment using native, unmodified GPCRs.
- Measure kinetic cellular responses.
- Monitor arrestin and G-limb signaling using the same modality.
- Detect GPCR responses simultaneously or in parallel.
- Quantify efficacy. Prioritize leads.
- Reliably detect agonist bias in living cells.