- Home
- Companies
- Ncardia Services B.V.
- Products
- Ncardia - Vascular Smooth Muscle Cells
Ncardia - Vascular Smooth Muscle Cells
Vascular smooth muscle cells contract or relax to change blood vessels volume and local blood pressure. Alterations in their functionality are associated with the progression of pathological conditions such as inflammation, atherosclersosis or pulmonary hypertension. In vitro physiologically relevant models can facilitate safety and efficacy screening of therapeutic candidates to prevent drug-induced changes in blood pressure and to find effective treatments. Ncardia Vascular Smooth Muscle cells are human iPSC-derived cells manufactured in a scalable process that provide an in vitro phenotypic model to reliable predict vasoactivity compound response.
- Minimal biological variability and high reproducibility
- Functional and physiologically relevant
- Sensitive compound-induced response
Ncardia Vascular Smooth Muscle Cells are a high purity cell population fully characterized by our scientists. As shown in the figure, the cells express specific markers of adult smooth muscle demonstrating their cellular identity.
Ncardia Vascular Smooth Muscle Cells are a physiologically relevant model for drug screening. These iPSC-derived cell model is fully functional and our scientific team has experience with a wide range of assays to evaluate the functions of your interest. As an example, the figure shows calcium transient analysis in response to endothelin-1.
Ncardia Vascular Smooth Muscle Cells are a sensitive iPSC-derived model available for high-throughput screenings with high reproducibility. It is also an in vitro model amenable for vascular safety assays which can provide precise concentration-response to detect vasoactive compounds. Our scientific team can develop assays and screenings to help you make more confident decisions in early drug discovery.