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Toxicology Services In North America
35 services found
by:Center for Toxicology and Environmental Health, L.L.C. (CTEH) based inNorth Little Rock, ARKANSAS (USA)
CTEH® provides both traditional pharmacokinetic modeling and physiologically-based pharmacokinetic (PBPK) modeling. CTEH® toxicologists are experienced in developing and applying traditional and PBPK modeling to reconstruct exposure and dose, support the establishment of health-based guidelines, and improve dose-response characterizations for assessments of chemical ...
by:Center for Toxicology and Environmental Health, L.L.C. (CTEH) based inNorth Little Rock, ARKANSAS (USA)
CTEH®’s pharmacology & toxicology professionals have extensive experience assessing the human toxicity of drugs and chemicals, and drug interactions and adverse reactions. CTEH® provides additional experience in pharmacokinetic analysis. Levels of drugs or chemicals in blood and/or urine are frequently key pieces of information in accidents, worker exposure ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
A successful ADC should be chemically and physiologically stable in blood stream, exert similar antigen binding pattern compared with the unconjugated antibody, and exhibit desired payload toxicological effects once internalized. ...
by:IDEXX BioAnalytics based inWestbrook, MAINE (USA)
In the nonstop race to develop lifesaving treatments, accuracy and speed are critical. They are the engines that propel research forward. IDEXX BioAnalytics Preclinical Testing Services is your research partner, supporting your work across clinical laboratory, anatomic laboratory, DABT and ACVP board-certified pathology, and small molecule ...
Manufactured by:ClearPoint Neuro, Inc. based inIrvine, CALIFORNIA (USA)
Study Design & Protocol Generation. Dedicated On-Site Pre-Clinical Support. Case Reporting & Post-Infusion Analysis. Safety & Toxicology Studies. GLP & Non-GLP Studies. Compatibility Testing. Quality & Regulatory ...
Manufactured by:Puracyp based inCarlsbad, CALIFORNIA (USA)
Puracyp’s cells contain the promoter/enhancer of these three P450 enzymes in addition to either CAR, AhR, or PXR. Panel screens are also useful for examining species differences in P450 induction and for toxicology studies using orthologs of human nuclear receptors. An example of results obtained in human cell lines utilizing our panel screen for PXR, AhR and CAR are shown ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Lead optimization is a complex and iterative process for identifying an improved drug lead with the goal of progressing to a preclinical candidate by altering the chemical structure of a confirmed hit. A diversity of properties such as target’s specificity, selectivity, pharmacodynamics, pharmacokinetics and toxicological properties are improved by modifying the chemical ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Immortalized cell lines and services are of ever-increasing importance in various aspects of biomedicine, toxicology and biotechnology. The cells can be used as model systems in phenotypic and drug screening, high content analysis, target identification, drug development, toxicology testing, gene editing studies, reporter assays. Besides, the immortalized cells ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Immortalized cell lines and services are of ever-increasing importance in various aspects of biomedicine, toxicology and biotechnology. The cells can be used as model systems in phenotypic and drug screening, high content analysis, target identification, drug development, toxicology testing, gene editing studies, reporter assays. Besides, the immortalized cells ...
by:North American Science Associates Inc.(NAMSA ) based inNorthwood, OHIO (USA)
NAMSA’s balance of trusted advisors and proven process lets us support clients across the entire medical device product development spectrum.Non-clinical studies are used to select prototypes and provide an understanding of device performance in a specific application. When it comes to non-clinical testing, you can rely on our safety evaluation studies (in vitro and in vivo ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Zebrafish have become the third largest vertebrate model organism after mouse and rat, and have been widely used in many fields such as developmental biology, genetics, basic medicine, pharmacology, toxicology, drug research and development, and ecological environment evaluation. Creative Biolabs provides a one-stop service platform for zebrafish gene knockout/knock-in and ...
Manufactured by:CD Formulation based inShirley, NEW YORK (USA)
Solubility and bioavailability issues run through drug metabolism and pharmacokinetic evaluation of candidate compounds, preclinical prescription development, and commercial formulation development. From the toxicological evaluation stage, CD Formulation has a perfect drug metabolism and pharmacokinetic support system, each experiment only consumes milligram-level API, which can ...
Manufactured by:Ascendia Pharmaceuticals based inNorth Brunswick, NEW JERSEY (USA)
We conduct pre-formulation assessments, bioavailability modeling, and formulation approach comparisons. We provide trial formulations suitable for animal studies, toxicology studies, and cGMP clinical trial materials for Phase I studies. At Ascendia, our core business is to develop practical, customized product formulations for poorly water soluble drugs. We offer rapid and ...
Manufactured by:Novodiax, Inc. based inHayward, CALIFORNIA (USA)
Use the Novodiax polymerized horseradish peroxidase (polyHRP) signal amplification technology (ihcDirect) and conjugate it directly to your humanized antibody-of-choice to enable rapid, sensitive IHC testing. Jumpstart your early humanized antibody-to-human tissue testing or ADME/toxicology studies to fail candidates ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
In vitro Skin Models (Human Skin Equivalent, FTSK, HSE) used under defined test conditions offer several advantages: i) since most models are composed of primary human cells, inter-species extrapolation is avoided; ii) in contrast to human skin specimens, repeated application of formulations can be performed for at least several weeks; iii) work with the ready to use tissue models do not require ...
by:Creative Proteomics based inNew York, NEW YORK (USA)
Compared with genomics, transcriptomics and proteomics, metabolomics provide a direct and global snapshot of all the metabolites, and tell the researchers what have happened, making it more and more popular in disease research, toxicology, environmental analysis, agriculture, biofuel development and ...
by:SoBran Inc. based inFairfax, VIRGINIA (USA)
Our scientific and technical experts assemble customized research programs with attention to your specific project requirements, timelines and budget. To support small animal preclinical toxicology and drug discovery, we offer an expanding range of services that meet GLP and non-GLP compliant in vivo research requirements. Program management is certified to the ISO ...
by:Andelyn Biosciences based inColumbus, OHIO (USA)
Andelyn Biosciences has more than 20 years of experience in cell and gene therapy manufacturing. We possess the capability and capacity to manufacture batches of plasmids in any size depending on client specifications – from small trials to clinical-scale plasmid ...
by:Ekotoxikologicke Centrum Bratislava s.r.o. based inBratislava, SLOVAKIA
The cosmetic product safety report shall, as a minimum, contain the ...
Manufactured by:Forge Biologics, Inc. based inGrove City, OHIO (USA)
Plasmid DNA is an essential component of gene therapy development and the starting point of Forge’s idea-to-impact manufacturing services to accelerate gene therapy programs from preclinical through clinical and on to commercial manufacturing. Forge’s plasmid production with single-use systems incorporates seamlessly into our optimized AAV manufacturing process for increased ...