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In Vitro Services In Usa Massachusetts
32 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
One of the main obstacles in drug development is how to deliver drugs effectively to target cells. In general, macromolecules such as proteins and mRNA cannot penetrate the cell membrane because the cell membrane has acquired protective mechanisms through evolution. However, viruses can deliver their genetic material into cells. Therefore, viruses and virus-like particles are widely used to ...
Manufactured by:Genovis Group based inKävlinge, SWEDEN
The custom antibody services include monoclonal and polyclonal antibody development, in vitro monoclonal antibody production, anti-idiotype antibody development and antibody ...
Manufactured by:Pion based inBillerica, MASSACHUSETTS (USA)
Pion Analytical Services offers comprehensive support for drug development activities by providing sophisticated assays, analyses, and interpretations that help in understanding pharmacokinetic parameters at an early stage in the development process. With our advanced instrumentation, in vivo-level insights can be obtained in vitro. Our services include establishing primary ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Far-western blot is a molecular biology method based on western blot technology that can be used to detect protein-protein interactions in vitro, especially interactions that do not require the natural structure of the target ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Therefore, studying new protein interactions can provide new directions for investigating the potential functions of proteins. Among many protein interaction identification experiments, pull-down is commonly used for in vitro protein interaction testing, and helps discover new interacting ...
Manufactured by:Nova Biomedical based inWaltham, MASSACHUSETTS (USA)
Nova Biomedical is a world leader in the development and manufacturing of advanced technology blood testing analyzers and diagnostic products. As the largest privately held in vitro diagnostic company in the U.S., we employ over 1,200 people, including over 125 scientists and engineers, and have sales and service subsidiaries in nine countries and distributors in over 92 other ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Specifically, Th3 cells primarily secrete TGF-β along with varying levels of IL-4 and IL-10. Natural regulatory T cells and Tr1 cells can suppress cytokine production in vitro through CD4+/CD25- T cells or antigen-specific Th1 or Th2 cells. ...
by:ProXyChem based in, MASSACHUSETTS (USA)
In collaboration with Apredica (Watertown, MA), ProXyChem can provide the following ...
by:Dyno Therapeutics based inWatertown, MASSACHUSETTS (USA)
Dyno’s lab provides the experimental capabilities that comprise the CapsidMap™ platform. The lab is responsible for creating novel vectors and assaying a diverse array of properties. Experiments at Dyno span pooled libraries with hundreds of thousands of AAV variants to assays focused on individual vectors. Our team rigorously employ diverse experimental approaches and innovate to ...
by:Revvity Gene Delivery (formerly SIRION Biotech) based inHamburg, GERMANY
In the discovery of oncology therapeutics, Antibody-drug conjugates (ADCs) are rapidly gaining momentum, with hundreds of candidates advancing through clinical development. Whether your priority lies in assessing the epitope binding of your construct, evaluating the cytotoxic potency of the payload, or scrutinizing the efficacy of the linker in cleaving, each facet demands meticulous ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Antibodies (Abs) are essential components of the adaptive immune system, which can combat infections and other harmful agents. Produced by B cells, Ab is either secreted or expressed on the plasma membrane at the present of B cell receptors (BCRs). Each Ab comprises two heavy chains (VH) and two light chains (VL). The VL each include a constant region varing only across different classes and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
In eukaryotic cells, the 3' end of mRNA is often extended with a poly(A) tail, a sequence of purine nucleotides. The poly(A) tail is a long chain of adenosine nucleotides of variable length. This tail is crucial for mRNA stability, transport, and translation. The analysis of mRNA's 3' poly(A) tail is a vital technique in studying the polyadenylation at mRNA molecules' 3’ ends, with significant ...
by:TÜV SÜD America Inc. based inWakefield, MASSACHUSETTS (USA)
In the medical field, practitioners utilize a range of devices to address patient health, from diagnosis to surgery. When the patient comes into contact with a medical device or material, it should fulfill its intended function without harming the patient. Therefore, all medical devices need to undergo a thorough biological risk assessment to protect the patient from any toxic, physiological, ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Drug affinity responsive target stability is a label-free small molecule probe technique under chemical proteomics first proposed by Lomenick et al. in 2009, which makes it possible to track and identify target proteins whose stability changes after binding with small molecules. To date, Drug affinity responsive target stability has been a focus in tracking proteins in animals, fungi, bacteria, ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Protein-based macromolecular drugs, typically organic compounds with molecular weights exceeding 1000, depend on cellular biosynthesis and are also known as biologics. Compared to traditional small molecule drugs, protein drugs are characterized by their high potency, strong specificity, low toxicity, clear biological function, and conducive to clinical application. Protein drugs are the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Receptors are biomolecules that can bind with hormones, neurotransmitters, drugs, or intracellular signaling molecules and are capable of inducing changes in cellular function. Receptors are categorized based on their cellular location into cell surface receptors and intracellular receptors. Each receptor typically has two active sites: one that recognizes and binds to the ligand and another ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Humans are highly organized systems comprised of approximately 3.72×1013 cells of various types, which maintain proper organ function and normal cellular homeostasis. Despite significant and revolutionary discoveries in the field of cell biology, the heterogeneity of cells still requires further investigation. Single-cell RNA sequencing (scRNA-seq) has become the latest method for revealing the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Bioactive peptides are short protein fragments of 2-50 amino acids in length that are linked by covalent bonds (called amide bonds or peptide bonds). Bioactive peptides have the advantages of simple structure, high biological activity, high specificity and low toxicity, and have broad prospects in the design and development of new peptide ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The inauguration of monoclonal antibodies (mAbs), derived from mice, were immunogenic in humans. These molecules were first synthesized in 1975 by Georges Köhler and César Milstein through the use of hybridoma technology. Later, in 1984, another milestone was achieved with the production of chimeric human antibodies via recombinant DNA technology. Hybridoma technology facilitates the creation of ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
T cells play a vital role in destroying pathogens and monitoring pathological cells. They are able to distinguish between self-antigens and non-self-antigens by surface T cell receptors (TCRs). Most human T cells express the classical TCRs, which consists of TCRα and TCRβ chains co-expressed with CD3 chains (γ, δ, ε, and ζ). The TCRα and TCRβ chains are composed of a variable (V) and a constant ...