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Detection and characterization of exosomes is necessary to stablish a relationship to disease and therapy. However, the low quantities obtained during isolation together with its cost, does not make it the ideal control for the development of reliable detection techniques. Synthetic exosomes are a very interesting tool to use as a standard in different applications such as the validation of exosome isolation tools or detection systems, among ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Exosomes are natural genetic material carriers, including mRNA, miRNA and siRNA. This material cannot be used in its naked form since it is very sensitive to degradation by ribonucleases, and it cannot enter the cells freely. Encapsulation in synthetic exosomes is an advantageous approach: it preserves the RNA and allows a path for cell ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Like other nanocarriers, synthetic exosomes can be used to treat different types of cancer successfully, by encapsulating the desired anti-tumoral drug or RNA and enzymes. Several studies have used engineered exosomes from dendritic or macrophage cells to release chemotherapeutic compounds as doxorubicin, paclitaxel miRNA or siRNA to induce antitumoral activity. Rodent mammary carcinoma, mice lung cancer, glioma and pancreatic cancer are just some targeted diseases in preclinical ...
ByNanovex Biotechnologies based in Llanera, SPAIN
In this aspect, the APO2L/TRAIL ligand is a key intermediate in immune cascades and is secreted in exosomes in natural conditions. Its alteration has been associated with rheumatoid arthritis. The administration of synthetic exosomes decorated with APO2L/TRAIL has been shown to be effective in reducing the hyperplasia and overall inflammation in this ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Drug delivery in the retina is normally performed through intravitreal injection but it is only suitable for compounds fitting a list of criteria like long half-lives. Decoration of engineered exosomes derived from retinal cells with hyaluronan binding peptides is a very effective alternative to intravitreal injection. ...
ByNanovex Biotechnologies based in Llanera, SPAIN
The delivery of therapeutical compounds such as RNA drugs into the brain presents the challenges of RNA preservation and the crossing of the blood brain barrier. Exosomes loaded with the specific siRNA sequences and marked with the neuron specific RVG peptide show specific accumulation in neurons, microglia and oligodendrocytes in the brain, effectively reducing genetic expression. ...
ByNanovex Biotechnologies based in Llanera, SPAIN
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Flow imaging microscopy detects aggregation of viral vectors such as AAVs, lentiviruses, and retroviruses as well as non-viral therapies like LNPs and ...
ByYokogawa Fluid Imaging Technologies, Inc. based in Scarborough, MAINE (USA)