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Colonizing Articles & Analysis
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Population growth, aging populations and increases in cancer incidence have necessitated new approaches to identifying effective treatments. One such approach involves the repositioning, or repurposing, of drugs already FDA approved in either non-oncology disease states and/or approved in a limited number of tumor types. The repurposing of these drugs for new indications represents an ...
The SpaCBA pili enable direct interaction with intestinal mucus layers, providing this strain with distinctive colonization dynamics compared to non-piliated strains. (3) L. gasseri ADH features a CRISPR-Cas system type II-A and intermediate hydrophobicity properties, positioning it as an optimal candidate for bacteriophage resistance studies and vaginal microbiome models. ...
The suppression of cell growth in lung cancer, breast cancer and colon cancer cells achieved through co-culture exhibited 7 to 23 times greater effectiveness than liposome delivery after PEVs were stored at −80℃. ...
Breath testing provides a non-invasive way to directly measure the presence of H2 and CH4 gases produced by the fermentation of undigested lactose in the colon. This method is particularly effective because it can detect lactose malabsorption regardless of its cause, whether congenital or acquired. ...
After 6 months, these cells migrated and colonized extensively throughout the brain and differentiated into all three major neural cell lineages. ...
To explore new possibilities for early detection and related treatment of centrosomes, CD BioSciences is involved in a wide range of service areas including but not limited to breast cancer, ovarian cancer, colon cancer, etc. Whether pathologic research or therapeutics development, CD BioSciences practically has experienced cytology experts with advanced equipment and tech to ...
What is biofilm? Biofilms are defined as communities of micro-organisms attached to a surface, or one another, and encased within a matrix of extracellular polymeric substance (EPS). The EPS makes up the largest component of the biofilm, and in the biological environment is generally composed of polysaccharides, proteins, glycolipids, blood products, cellular debris, extracellular enzymes, metal ...
Short-chain fatty acids can be absorbed by the cecum, colon and rectum, then enter the mesenteric vein and finally enter the blood circulation. ...
Bile Acid Diarrhea Bile acid diarrhea (BAD) is a condition wherein excess bile acids in the colon lead to increased water secretion and accelerated colonic transit, culminating in watery diarrhea. ...
In a mouse model, oral administration of IL-22 mRNA-loaded LNP significantly increased IL-22 expression in the colonic mucosa and accelerated the healing of colitis. These results suggest that oral delivery of mRNA-loaded LNP is a viable strategy for treating gastrointestinal diseases by reestablishing the intestinal microenvironment. 2) Inhalation is also a preferred route of ...
For more serious tissue defects or damages that cannot be repaired quickly under natural conditions, nano-dressing is applied to the wound to provide a “platform” for the migration and colonization of surrounding normal cells to the defect area. These accelerate the growth of regenerative cells and matrix secretion, to promote the repair of the defect. ...
Calu-3 cells (Homo sapiens lung epithelial cells) and MDCK II cells (Canis familiaris kidney cells) were obtained from the American Type Culture Collection (ATCC). Caco-2 cells (Homo sapiens colon epithelial cells) were provided by the Institute for Medical Virology and Epidemiology of Viral Disease, Department of Molecular Virology, University Hospital Tuebingen, Germany. ...
Additionally, CD73 expression was found to be downregulated in advanced-stage prostate, laryngeal, and high-grade colon carcinomas. Lower CD73 expression levels were observed in poorly differentiated and advanced-stage endometrial carcinomas compared to normal and well-differentiated, early-stage tumors, with higher CD73 expression associated with improved overall survival[23]. ...
Trop-2 protein is highly expressed in a variety of tumors, such as pancreatic cancer, breast cancer, colon cancer, ovarian cancer, and non-small cell lung cancer. Its high expression is also closely related to shortened survival and poor prognosis of tumor patients, and it is a popular target in the ADC field after HER-2. ...
Transcription of genes such as cyclin D1, cyclin-dependent kinase Cdk2, and c-myc is regulated by NF-κB. In cancers such as breast, colon, and lymphoma, persistent activation of NF-κB leads to abnormal activity of cell cycle-related proteins. ...
They found that certain cancers, such as uterine, bladder, and colon cancers, exhibit greater variability in TMB values compared to lung and head cancers. ...
After 6 months, these cells migrated and colonized extensively throughout the brain and differentiated into all three major neural cell lineages. ...
IL-17B is not produced by activated T lymphocytes, but IL-17B has been found in neutrophils, B cells, neuronal cells, stromal cells, and colon epithelial cells. The expression of IL-17B in the synovium and pancreatic tissue of patients with rheumatoid arthritis (RA) increases, and IL-17B enhances the effect of TNF-α in fibroblasts, which may be important for the immune ...
TSLP and cancer New functions of TSLP have been discovered in the induction and progression of various tumors, including solid tumors such as breast, colon, and pancreatic cancers, as well as hematological malignancies like B-cell acute lymphoblastic leukemia (B-ALL). ...
In a breakthrough discovery, scientists from the National University of Singapore's Yong Loo Lim School of Medicine (NUS Medicine) have identified a feature of CPS that helps bacteria colonize the human airways. The study showed that the structure of the CPS capsule and the types of connections and combinations are very important for bacteria to better attach and survive on the ...