Immune Recognition Articles & Analysis
8 articles found
This ability is vital because many therapeutic proteins require specific glycosylation patterns to be effective and to avoid immune recognition. Advantages of Using CHO Cells CHO cells bring numerous advantages to recombinant protein expression: One of the primary benefits is their ability to grow in suspension cultures, facilitating scale-up and reducing ...
ADCs with PEG linkers show slower plasma clearance and longer half-life. l Reduced Immunogenicity: By preventing protein aggregation and shielding payload epitopes, PEG linkers lower the risk of immune recognition. PEG-encapsulated ADCs often exhibit reduced antibody responses and toxicity. l Enhanced Targeting: More soluble and stable ADCs better reach tumor ...
Steric shielding, protecting the drug from enzymatic degradation and immune recognition. Benefits of PEGylation in Drug Development 1. Prolonged Half-Life PEGylation increases hydrodynamic volume, preventing rapid kidney filtration and extending plasma half-life. ...
Watertown, MA – March 24, 2025 – Biopharma PEG, a leading supplier of high-quality polyethylene glycol (PEG) derivatives, highlights its innovative product DSPE-PEG-Mannose, an advanced biomedical polymer with significant potential in drug delivery, tumor-targeted therapy, tissue recognition, and adhesion.Structural Advantages of DSPE-PEG-MannoseDSPE-PEG-Mannose is composed of ...
Mechanism of Vaccine Adjuvants Vaccine excipients, including adjuvants, are added to vaccine formulations to enhance the immune response by providing necessary signals to the immune system. Adjuvants can stimulate the innate immune system, improving the recognition of antigens and promoting a more robust adaptive ...
It is involved in the formation and development of the tumor microenvironment (TME) and plays an important role in regulating immune responses. Researchers state that enoblituzumab, as a new treatment approach, primarily works by relieving the inhibition of the immune system's recognition and elimination of cancer cells by B7-H3. It triggers the ...
To protect transplanted islets from immune recognition, microencapsulation is commonly used,27,28 wherein isletembedded microcapsules are implanted either subcutaneously or intraperitoneally.29–32 While each individual microcapsule is able to support enough diffusion for islet survival, combining tens to hundreds of thousands of microcapsules in the ...
Glycans in glycoprotein molecules can affect the conformation, polymerization, dissolution and degradation of the protein part and participate in the mutual recognition and binding of glycoproteins. Glycosaminoglycans in proteoglycan molecules Proteoglycans are dominated by glycan content, and glycosaminoglycans are covalently linked to different core proteins to form sugar ...