Immune Recognition Articles & Analysis
2 news found
Epitope mapping is a fundamental tool in immunology and molecular biology, used to pinpoint the characterizing monoclonal antibodies, guiding vaccine formulation, and understanding immune recognition. It also plays a key role in optimizing antibody affinity, minimizing cross-reactivity, and evaluating the functional impact of epitope location on therapeutic ...
“With the proteolytic shedding of the α1 and α2 domains of MICA/B being recognized as a common tumor escape mechanism, we are encouraged that our novel CAR design, which uniquely targets the α3 domain of MICA/B, has shown the potential to overcome shedding and restore NK and T cell-mediated tumor immunity. We look forward to treating patients with FT536 as ...