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Patient Enrollment Articles & Analysis

24 articles found

Emerging therapy for HFpEF: SGLT2 inhibitors

Emerging therapy for HFpEF: SGLT2 inhibitors

After screening 11,583 patients, the study enrolled 5,988 patients with symptomatic heart failure and preserved ejection fraction (EF > 40%). ...

ByUltromics Limited


Antibody-Drug Conjugates For The Treatment of Prostate Cancer

Antibody-Drug Conjugates For The Treatment of Prostate Cancer

DSTP3086S, a humanized IgG1 anti-steap1 monoclonal antibody related to MMAE, demonstrated safety and significant antitumor activity in a Phase I trial of 77 mCRPC patients. PSA decreased by 50% in 18% of patients, local radiation reaction occurred in 6% of patients, and transformation to benign cycle tumor cells <5 in 60% of ...

ByHunan Huateng Pharmaceutical Co. Ltd.


How eCOA Improves Patient Experience and Data Quality

How eCOA Improves Patient Experience and Data Quality

With the rising demand for improving patient safety in clinical trials, the adoption of patient-centric solutions is considered the best route to enhance data accuracy and experience automated workflows. This is where eCOA comes into play. In this blog post, we will find out how electronic clinical outcome assessments are helping the clinical trials industry handle the ever-growing list of ...

ByClinion


Spine-Intra-Abdominal Pressure (SIAP) - Case Study

Spine-Intra-Abdominal Pressure (SIAP) - Case Study

Study background The objective of this study is to demonstrate the ability of the inflatable Prone Supports (IPS) to lower the IAP of patients in the prone position. Whenever the patients’ position is changed to prone, the IAP is increased due to abdominal compression.1,2 It has been demonstrated previously that an increased IAP is linked to increased ...

ByErgotrics NV


A Combination of Ramucirumab Plus Pembrolizumab Lengthened Survival For Some Lung Cancer Patients

A Combination of Ramucirumab Plus Pembrolizumab Lengthened Survival For Some Lung Cancer Patients

The randomized phase 2 S1800A study enrolled 136 eligible patients with stage IV or recurrent non-small cell lung cancer. These patients had previously received ICI therapy. In all cases, the patients' tumors eventually became resistant to these drugs and grew or spread before the patients were ...

ByHunan Huateng Pharmaceutical Co. Ltd.


Vectorious Begins the VECTOR-HF II Study of its Implantable In-Heart Sensor for Left Atrial Pressure-Guided Patient Self-Management of Heart Failure

Vectorious Begins the VECTOR-HF II Study of its Implantable In-Heart Sensor for Left Atrial Pressure-Guided Patient Self-Management of Heart Failure

For the first time, heart failure patients can have full visibility of their hearts’ LA pressure and self-adjust their medication to stop further deterioration and avoid hospitalizations April 26, 2022 08:30 AM Eastern Daylight Time TEL AVIV, Israel–(BUSINESS WIRE)–Vectorious Medical Technologies Ltd., today announced that it has ...

ByVectorious


ABILITY Diabetes Global enrolls thousandth patient: A Cardinal Milestone Achieved

ABILITY Diabetes Global enrolls thousandth patient: A Cardinal Milestone Achieved

ABILITY Diabetes Global (Randomized Comparison of Abluminus DES+ Sirolimus-Eluting Stents versus Everolimus-Eluting Stents in Coronary Artery Disease Patients with Diabetes Mellitus Global) started off with the index patient enrolment on 11th June 2020 in Italy (at the peak of the 1st wave of COVID-19 pandemic) by P.I. ...

ByConcept Medical Inc.


Oncology - Complex Clinical Trials in The Fastest Growing Therapeutic Area

Oncology - Complex Clinical Trials in The Fastest Growing Therapeutic Area

There’s been a huge emphasis on developing new treatments to improve survival in patients with cancer, but these trials have become a costly undertaking for sponsor companies. ...

BySeascape Clinical


Paxlovid: Spring of Caronic Anhydrides

Paxlovid: Spring of Caronic Anhydrides

This pivotal study (NCT04960202) enrolled 2,246 patients with COVID-19, 1,120 received Paxlovid and 1,126 received placebo. ...

ByHunan Huateng Pharmaceutical Co. Ltd.


ReActiv8-B Trial 2-Year Data Publication in Neuromodulation

ReActiv8-B Trial 2-Year Data Publication in Neuromodulation

These results provide evidence of long-term effectiveness and durability of restorative neurostimulation in patients with disabling CLBP, secondary to multifidus muscle dysfunction. ...

ByMainstay Medical


Therapeutic HL-Contact Lens versus Standard Bandage Contact Lens for Corneal Edema: A Prospective, Multicenter, Randomized, Crossover Study

Therapeutic HL-Contact Lens versus Standard Bandage Contact Lens for Corneal Edema: A Prospective, Multicenter, Randomized, Crossover Study

Prospective, multicenter, randomized, crossover study. Chronic corneal edema patients were randomized to one of two arms. The first arm was fitted with the Therapeutic Hyper-CL™ lens while the second arm was fitted with a standard soft bandage contact lens. ...

ByEyeYon Medical Ltd


Changes in MRE in HCV patients who achieve SVR

Changes in MRE in HCV patients who achieve SVR

In this study, we investigated the changes of liver stiffness by magnetic resonance elastogaraphy (MRE) during DAA therapy. A total of 308 patients were enrolled in the study. Liver stiffness was measured twice before and after DAA treatment using MRE and time-course change of liver stiffness was investigated. ...

ByResoundant, Inc.


‘First In-Heart Microcomputer,’ EVAR Suture-Delivery Catheter Named Top CRT Innovations

‘First In-Heart Microcomputer,’ EVAR Suture-Delivery Catheter Named Top CRT Innovations

In real time, a physician can remotely adjust the patient’s medication based on the data. The device is the subject of the VECTOR-HF study, which is designed to enroll 45 patients with chronic New York Heart Association heart failure class III, hospitalization for worsening heart failure, or elevated ambulatory B-type natriuretic peptide ...

ByVectorious


Results Published from FIH Study of Thrombolex’s Bashir Endovascular Catheter

Results Published from FIH Study of Thrombolex’s Bashir Endovascular Catheter

” As summarized in Circulation: Cardiovascular Interventions, this prospective, multicenter, single-arm study enrolled patients with symptomatic PE and RV/LV diameter ratio ≥ 0.9 as documented by computer tomography angiography. ...

ByThrombolex, Inc.


Cleveland Clinic: First Case Completed in Feasibility Study of Non-Radiation-Based EVAR Navigation Platform

Cleveland Clinic: First Case Completed in Feasibility Study of Non-Radiation-Based EVAR Navigation Platform

” MOTION is designed to enroll 30 patients between Cleveland Clinic and a second study site, UNC Medical Center in Chapel Hill, North Carolina. ...

ByCenterline Biomedical


A Paradigm Shift in the Treatment of Venous Thromboembolic Disease

A Paradigm Shift in the Treatment of Venous Thromboembolic Disease

The mainstay of treatment for patients with DVT and PE has historically been systemic anticoagulation. ...

ByThrombolex, Inc.


Innovation Spotlight: Alucent Biomedical | Can we Make ‘Stents’ Obsolete?

Innovation Spotlight: Alucent Biomedical | Can we Make ‘Stents’ Obsolete?

Where is the technology in development and what is next for the company? We began enrolling patients in our ACTIVATE I first-in-human trial in May of 2020. The phase I study is evaluating the safety and efficacy of the AlucentNVS technology in patients with PAD of the lower extremities. The first patients were ...

ByAlucent Biomedical Inc.


San Diego VA Hospital - 4.6 MW CHP System - Case Study

San Diego VA Hospital - 4.6 MW CHP System - Case Study

The San Diego VA Hospital has 304 hospital beds; 510,000 annual outpatient visits; 54,000 enrolled patients;7000 admissions; and 2000 full-time employees. VASDHS is affiliated with the University of California, San Diego School of Medicine. ...

BySolar Turbines Incorporated


Ancora Heart sees positive early results with Accucinch in systolic heart failure

Ancora Heart sees positive early results with Accucinch in systolic heart failure

The results were presented last week at the Transcatheter Cardiovascular Therapeutics 2019 conference in San Francisco. Endpoints, results Enrollment in the Corcinch FMR study recently wrapped up, with 35 patients being treated with the Accucinch at 15 heart centers. ...

ByAncora Heart, Inc


Combatting the Opioid Crisis with Cell Therapies for Chronic Back Pain

Combatting the Opioid Crisis with Cell Therapies for Chronic Back Pain

IDCT is an allogeneic, non-surgical cell therapy, meaning it’s an injectable treatment that is produced from donor tissue (as opposed to the patient’s own) and available off-the-shelf. Because IDCT is manufactured from cells that are native to the intervertebral disc, we have a therapy that is ideally suited for use in patients with DDD. ...

ByDiscGenics, Inc.

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