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Preclinical Phase Articles & Analysis

9 articles found

Innovative Preclinical Alfa Cytology alfaCAR-T Solutions: Revolutionizing the CAR-T Development Platform

Innovative Preclinical Alfa Cytology alfaCAR-T Solutions: Revolutionizing the CAR-T Development Platform

The preclinical phase is critical for identifying the potential efficacy and safety of CAR-T therapies before moving to human trials, and Alfa Cytology's approach is designed to optimize this stage. ...

ByAlfa Cytology


Drug Screening in Animal Models: A Crucial Step in Biomedical Research

Drug Screening in Animal Models: A Crucial Step in Biomedical Research

For instance, larger animals such as dogs or pigs are often preferred in the study of cardiology, while zebrafish provide a rapid assessment of pharmacokinetics and toxicity. Phases of Drug Screening Drug screening typically unfolds in several key phases: Preclinical Testing: Before any drug can enter human trials, it undergoes extensive ...

ByCreative Biogene


Adaptive Designs in nQuery - Case Study

Adaptive Designs in nQuery - Case Study

He has worked in the leading CROs in the industry and has assisted pharmaceutical companies with the drug development process with clinical trials, programs, and portfolio designs. His experience extends from preclinical, phases I through IV, biosimilar, and bioequivalent using fixed, adaptive designs, stand-alone, and master protocols in multiple therapeutic ...

ByStatsol


Conceptual Considerations for Device-Based Therapy in Acute Decompensated Heart Failure

Conceptual Considerations for Device-Based Therapy in Acute Decompensated Heart Failure

As summarized in the Table and illustrated in Figure 1, each of these mechanisms has a drug-based precedent and the devices are in various phases of clinical study. In general, in contrast to their drug-based precedents, which may have off-target and secondary mechanisms of action, these devices in principle more specifically target the pathophysiologically deranged mechanism of ...

BySecond Heart Assist, Inc.


The Toxicity Atlas - One year later

The Toxicity Atlas - One year later

So, I’ve spent the past year digging deep into drug databases and I’ve noticed there are three types of drug information: The chemical properties of a drug The effect a drug has on cell cultures and animals (preclinical research) The effect a drug has on humans (clinical research) Each type of information can be found on chemical, ...

ByMedstone Holding BV


Four Well-Established Strategies Used in Hit Identification

Four Well-Established Strategies Used in Hit Identification

The major preclinical phases of peptide drug discovery encompass initial target identification and validation, hit identification, high throughput screening, lead optimization, etc. ...

ByCreative Peptides


Lessons learned in medical robotics development with Enrique Romo, VP Research & Innovation Noah Medical

Lessons learned in medical robotics development with Enrique Romo, VP Research & Innovation Noah Medical

Everyone wants to be innovative, but rarely is innovation a lightning strike of genius – especially within the robotics industry. Instead, it is an intentional process and methodology. This process is refined and modified over time to enable an organization’s ability to think creatively and execute ...

ByNoah Medical


Q&A with Chrys Maoudis, Research Scientist at Regeneus

Q&A with Chrys Maoudis, Research Scientist at Regeneus

Our focus on pain under this grant has led to the generation of preclinical datasets for both our Progenza™ and Sygenus platforms. ...

ByRegeneus Ltd.


Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding

Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding

Other proteins with altered levels, such as Kunitz-type protease inhibitor 1 and beta-2-microglobulin, were not substrates in biochemical assays, suggesting an indirect affect of the MMPI, which might be important in drug development as biomarkers or, in preclinical phases, to predict systemic drug actions and adverse side effects. ...

ByAmerican Society for Microbiology (ASM)

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