T Cell Receptor Articles & Analysis
25 articles found
Cancer treatment has witnessed transformative advancements over the past few decades, notably with the emergence of CAR-T (Chimeric Antigen Receptor T-cell) therapy. This revolutionary therapy harnesses the body's immune system by genetically engineering T-cells to target and destroy cancer ...
Among the various forms of immunotherapy, CAR T-cell therapy (Chimeric Antigen Receptor T-cell therapy) has shown promise, particularly in treating acute lymphoblastic leukemia (ALL), especially in children and young adults. This therapy involves genetically modifying a patient’s ...
Scientists are using a variety of gene delivery strategies to insert new genes into cells. One common biological system is viral gene delivery, where the viral vectors are modified to carry the genes and deliver them to the target cells. ...
The emergence of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of certain cancers, providing a promising targeted approach to eliminate cancer cells. However, the monitoring and detection of CAR-T cells in vivo remain a challenge in the ...
Immune receptors are diverse and include pattern recognition receptors (PRR), Toll-like receptors (TLRs), killer activating and killer inhibitory receptors (KAR and KIR), complement receptors, Fc receptors, B cell receptors, and T ...
The T cell antigen receptor (TCR) is a characteristic marker of T cells, playing a crucial role in the immune system. ...
Cell penetrating peptides provide a solution to this problem. They can form complexes with the therapeutic molecules, allowing them to enter cells together. ...
This cutting-edge technology holds great potential in treating diseases through targeted drug delivery. CAR-T/CAR-NK Cells Development for Drug Delivery Systems As a groundbreaking advancement in immunotherapy, CAR-T (Chimeric Antigen Receptor T-cell) and CAR-NK (Chimeric Antigen ...
The antigen and antibody responses are generally referred to as specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune responses, which are part of the body's natural defense system. ...
The company has recently launched TCR-seq, a powerful service that enables rapid and efficient analysis of T-cell receptor (TCR) diversity and clonality, providing critical support for immune and cancer research. ...
One such mechanism are the so-called “immune checkpoints”: these are molecules found on the surface of T cells. When a cell binds both the T-cell receptor (the receptor specific for a given antigen, that gives a T cell its ...
Chimeric antigen receptor T cells (CAR-T) and T cell antigen receptor chimeric T cells (TCR-T) are currently the "top stream" in adoptive T cell tumor immunotherapy. ...
Recently, in a study published in Molecular Cancer Therapeutics entitled "Olfactory Receptor OR2H1 is an effective target for CAR T cells in human epithelial tumors," scientists from Moffitt Cancer Research Center identified a novel potential target for CAR-T cells called OR2H1 through research, which may help ...
The Future of Cancer Diagnostics The diagnostics that we and others are developing measure the genome (an organism’s genes), proteome (proteins expressed by the genome) or the immune repertoire (an immune system’s T-cell receptor and B-cell receptors). We are attempting to fundamentally understand ...
Chimeric antigen receptors (CARs) and engineered T cell receptors (TCRs) are the main adoptive immunotherapies in recent years. TCR-engineered T cells express tumor antigen-specific receptors with alpha and beta chains generated from high-quality, high-affinity clones of ...
T cells infiltrate diabetic patients' islets, and in a mouse model, diabetes can be passed from one animal to another via T cell relay. As a result, immunotherapy that targets T cells has attracted a lot of attention. Anti-CD3 immunotherapy Orthoclone (OKT3) was created in 1979 to target the ...
T cells can be separated into two subpopulations based on the expression of T-cell receptors (TCRs). αβ T cells, expressing expressing αβ TCR, recognize peptide antigens, such as those expressed by cancer cells. αβ T cells are ...
Heart failure, liver disease, and kidney failure are just a few of the major conditions that can result from cardiac fibrosis. The FDA approved CAR-T cell therapy, also known as chimeric antigen receptor T-cell therapy, as the first CAR-T cell therapy to be marketed for the ...
Many analyses, such as differential gene expression analysis, immunological gene signature analysis, gene pathway analysis, T/B-cell receptor inference, HLA inference, and viral transcript quantification, can be performed on the data after it has been sequenced. ...
CD8+ T cells recognize presented peptides via their highly specific T cell receptors, which in turn determines cell stimulation, proliferation and cytotoxic activity. ...