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T Cell Receptor Equipment & Supplies
42 equipment items found
Manufactured by:Oxford Vacmedix UK Limited based inOxford, UNITED KINGDOM
In the image below the Recombinant Overlapping Peptide is the “Antigen” being presented to the T Cell Receptor (TCR). This then triggers the growth of T Cells that will recognise the same marker on cancer cells leading to their destruction. ...
Manufactured by:Immudex ApS based inVirum, DENMARK
dCODE Dextramer technology enables the analysis of antigen-specific T cells by NGS or single-cell multi-omics. dCODE Dextramer adds a unique DNA barcode to the MHC Dextramer® reagent to detect antigen-specific T cells by NGS or single-cell multi-omics. High-avidity binding to ...
Manufactured by:Regeneron Pharmaceuticals Inc. based inTarrytown, NEW YORK (USA)
elociT™ is our unique mouse technology for producing fully human therapeutic T-cell receptors (TCR) against tumor and viral antigens. Regeneron uses this technology as part of its efforts to discover and develop novel immuno-oncology therapeutic candidates, including combination approaches and to assist our collaborators in producing fully ...
by:Sorrento Therapeutics, Inc. based inSan Diego, CALIFORNIA (USA)
Sorrento utilizes a proprietary knock-out knock-in (KOKI) technology to modify normal healthy donor derived T cells to genetically engineer them to express the dimeric antigen receptor into T-cell receptor (TCR) alpha chain constant region (TRAC). In this manner, TRAC is knocked out and ...
Manufactured by:Celularity Inc. based inFlorham Park, NEW JERSEY (USA)
Chimeric Antigen Receptor T cells (CAR-T) are genetically engineered T cells that are modified to express an artificial T cell receptor on their surface that binds and targets cancer proteins in an HLA-independent ...
Manufactured by:ProImmune Ltd. based inOxford, UNITED KINGDOM
Human MR1 Tetramers detect MAIT cells with human MR1 tetramers. ProImmune is the leading commercial source worldwide for fluorescently labeled human MR1 tetramers. MR1 complexes bind to T cell receptors on mucosal-associated invariant T (MAIT) cells. MAIT cells have a particular ...
by:Ionpath, Inc. based inMenlo Park, CALIFORNIA (USA)
Background:Arginase-1 is expressed by liver cells, myeloid-derived suppressor cells (MDSCs), macrophages, and neutrophils. In mammals, there are three enzymes that metabolise arginine: two arginase isoforms (ARG1, ARG2) and inducible nitric oxide synthase (iNOS). Arginase-1 catalyzes the breakdown of L-arginine into L-ornithine and urea as the final step in the ...
Manufactured by:10x Genomics based inPleasanton, PENNSYLVANIA (USA)
Multiomic profiling of immune diversity, cell by cell. Chromium Single Cell Immune Profiling provides a multiomic solution to your immunology questions. Analyze full-length, paired B-cell or T-cell receptors, surface protein expression, antigen specificity, and gene expression, ...
Manufactured by:TC BioPharm based inHolytown, UNITED KINGDOM
At TC BioPharm, we apply chimeric antigen receptor T cell (CAR-T) technology to gamma delta T (GDT) cells. This takes advantage of the endogenous gamma delta T cell receptor (TCR), and combines it with chimeric antigen receptors. ...
Manufactured by:ProImmune Ltd. based inOxford, UNITED KINGDOM
Best in class MHC Class II Monomers: ProM2® Class II MHC Monomers are pre-biotinylated and can be readily adapted either to detect and separate single-antigen specific T cells or implement specialist solid or solution phase immunoassays for measuring interactions of predefined MHC Class II-peptide complexes with ligands such as monoclonal antibodies, ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Tebentafusp (IMCgp100) is a bispecific fusion protein to target gp100 peptide-HLA-A*02:01 (a melanoma-associated antigen). Tebentafusp guides T cells to kill gp100-expressing tumor cells via a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 ...
Manufactured by:ProImmune Ltd. based inOxford, UNITED KINGDOM
CD1d Tetramers the world’s leading product for tracking NKT cells. Detect NKT Cells with CD1d Tetramers: ProImmune is the leading commercial source worldwide for fluorescently labeled human and mouse CD1d tetramers. CD1d-lipid complexes bind to T cell receptors of NKT cells of a particular ...
by:Intellia Therapeutics, Inc. based inCambridge, MASSACHUSETTS (USA)
We plan to initiate patient screening for a first-in-human Phase 1 study of NTLA-5001, a WT1-directed TCR T cell therapy for the treatment of AML, by the end of 2021. Our first ex vivo development candidate seeks to treat acute myeloid leukemia (AML) by engineering autologous T cell receptors (TCR) directed ...
Manufactured by:Ardigen based inKraków, POLAND
Accelerate discovery and improve safety of TCR therapies using Artificial Intelligence. Following the unique opportunity for curing patients provided by the development of cell therapies (e.g. TCR discovery), Ardigen has set on the path to advance the field with its Artificial Intelligence platform. Many challenges stand in the way of successful therapy discovery and development. Let us know how ...
Manufactured by:Kiadis Pharma NV based inAmsterdam, NETHERLANDS
Accessing a new repertoire of targets. Two classes of molecule with therapeutic potential that are not currently addressed by antibody drugs are G-protein-coupled receptors and ion channels, largely because they display small epitopes not accessible to traditional antibodies and their sequence is often conserved and thus less likely to be ...
by:Celluris based inSão Paulo, BRAZIL
The chimeric T cell antigen receptor therapy, also known as CAR-T, is an immunotherapy that is innovating the treatment of hematological and solid tumors. This new technology is considered less aggressive than conventional treatments, since it focuses only on cancer cells, not attacking healthy ...
Manufactured by:ProImmune Ltd. based inOxford, UNITED KINGDOM
ProM1™ MHC Class I Monomers, biotin labeled enabling specialist assays for defined MHC Class I peptide target ...
by:Vor Biopharma based inCambridge, MASSACHUSETTS (USA)
Licensed from the National Institutes of Health, VCAR33 is a CD33-directed chimeric antigen receptor T cell (CAR-T) therapy. A T cell therapy using the same CAR construct as VCAR33 is being studied in a multi-site Phase 1/2 clinical trial as an autologous monotherapy bridge-to-transplant for ...
Manufactured by:Adaptive Biotechnologies based inSeattle, WASHINGTON (USA)
We are currently leveraging our TCR discovery capabilities to enable commercialization of novel therapies by collaborators. In the future, we may explore expanding our end-to-end capabilities for the development of cellular therapies and vaccines. TruTCR is summarized in the figure ...
Manufactured by:10x Genomics based inPleasanton, PENNSYLVANIA (USA)
Consistent results: Reduce variability in single cell data, generating reproducible and consistent results. Maximum lab productivity: Free up hands-on time for other experiments with walk-away convenience for single cell workflows. Integrated and validated: Automate single cell partitioning, barcoding, and library prep with one optimized instrument. Many single cell assays: Efficiently ...