Tumor Mutation Articles & Analysis
8 articles found
Circulating Tumor Cells, or CTCs, are cancer cells that have shed from the primary tumor and enter the bloodstream, where they can travel and potentially lead to metastasis. ...
This phenomenon offers a remarkable opportunity in cancer therapy. Tumors often exhibit mutations that can be exploited for targeted treatments. For example, patients with mutations in the BRCA1 or BRCA2 genes, which are crucial for DNA repair, are susceptible to drugs that inhibit PARP (Poly ADP Ribose Polymerase). ...
Discover how matched tumor-normal sequencing can help clinical researchers detect the somatic origin of variants with certainty. In the era of precision oncology, it has become increasingly common for patients diagnosed with cancer to undergo tumor sequencing. Identifying the mutations that make up a tumor’s genomic ...
ESMO updated its recommendations for NGS in advanced cancers this year, urging broader use of NGS in additional cancer types and the inclusion of tumor-agnostic biomarkers. The ESMO Precision Medicine Working Group (PMWG) first published its recommendations for when to use next-generation sequencing (NGS) in routine practice for patients with metastatic cancers in 20201. At that time, based ...
Enhancing Cancer Genomic Research with WES Mutations occurring within the whole exome regions of the cancer genome play a pivotal role in tumor development. ...
By conducting and integrating genomes databases, we have the ability to systematically analyze disease genomics, such as cancer genomics, to break through the limitations of analyzing high-throughput datasets, and to facilitate the understanding of complex issues such as molecular mechanisms of tumor formation, recurrence and drug resistance, tumor heterogeneity, ...
Due to the large amount of data, these researchers were also able to compare the patient’s LAG+ immunophenotype with other known response biomarkers—specifically, PD-L1 status and tumor mutation burden. They found that this immunophenotype provides new and independent information about the patient's prognosis, rather than just echoing other ...
Cancer cells arise through sequential acquisition of mutations in tumor suppressors and oncogenes. c-Jun, a critical component of the AP-1 complex, is frequently overexpressed in diverse tumor types and has been implicated in promoting cellular proliferation, migration, and angiogenesis. ...