In Vivo System Articles & Analysis
5 news found
They have demonstrated these drugs: 1) are highly specific for PfGARP binding, 2) are non-toxic in multiple in vitro and in vivo systems, 3) have excellent pharmacokinetic properties, and 4) rapidly clear parasitemia in animal models. ...
Biocompatibility assessment is an essential part of the overall safety evaluation of medical devices. Biocompatibility systemic toxicity tests are in vivo systemic tests used to assess systemic damage or activation of a system, not damage to individual cells or organs. Systemic toxicity tests ...
BySTEMart
However, the clinical utility of IL12 has been limited by toxicities stemming from systemic cytokine exposure. Harnessing the power of IL12 in a therapeutic setting will require technologies that provide tight control of IL12 expression and localization. In mouse models, Obsidian demonstrates that membrane-bound IL12 (mbIL12) increases activity at the tumor site in ...
Kawahara was a member of the founding management team and Corporate Director, Planning and Business Development, for Xenogen Corporation (Alameda, CA), developed IVIS® in vivo biophotonic imaging system, and held positions of increasing responsibility at Becton Dickinson and Company (San Jose, CA) including Director, Reagents and Applications Development, for ...
The selected ADCs will be evaluated on its anti-tumour activity in in vitro and in vivo systems and will then be considered for IND-enabling studies. The parties hope to leverage IntoCell's validated linker system and novel payloads with Ab Studio's antibodies with enhanced and optimised internalisation properties. "We are excited to start a new ...