CAR-NK - Cell Therapies for Solid Tumors

Natural killer (NK) cells, as their name implies, play an important role in ridding the body of cancer and viruses. NK cells are emerging as an increasingly important cell type for therapeutic development. Solid tumors are particularly challenging to treat and CAR-T cells have largely underperformed in the solid tumor setting. NK cells, however, inherently target both primary solid tumors and metastases. We are developing CAR-NK therapies for the treatment of multiple solid tumor types. We are able to differentiate NK cells from induced pluripotent stem cells (iPSCs) that we edit in multiple ways to address targeting, trafficking, proliferation, and overcoming the immunosuppressive tumor microenvironment.