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Immunosuppression Equipment & Supplies
118 equipment items found
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor ofmTORC1. Rapamycin is anautophagy activator, an ...
Manufactured by:Scandinavian Biopharma based inSolna, SWEDEN
Grafalon contains anti-human T-lymphocyte immunoglobulin from rabbits and belongs to a group of medicines called immunosuppressants. Immunosuppressants are used to prevent the body from rejecting transplanted ...
Manufactured by:Creative Peptides based inNew York, NEW YORK (USA)
Everolimus is a Kinase Inhibitor and mTOR Inhibitor Immunosuppressant. The mechanism of action of everolimus is as a Protein Kinase Inhibitor and Cytochrome P450 3A4 Inhibitor and P-Glycoprotein Inhibitor and Cytochrome P450 2D6 Inhibitor and mTOR Inhibitor. The physiologic effect of everolimus is by means of Decreased Immunologic Activity. ...
Manufactured by:Altucell, Inc. based inNew York, NEW YORK (USA)
Encapsulated cell therapy is an emerging area of biopharmaceutical research that aims to unleash the therapeutic potential of cells to treat serious diseases without the need for immunosuppression. Altucell has developed patented, proprietary engineered cells that are combined with a patented encapsulation technology to create effective ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Methotrexate (Amethopterin), anantimetaboliteandantifolateagent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute ...
Manufactured by:PharmAbcine Inc. based inYuseong-gu, SOUTH KOREA
PMC-309 is an engineered monoclonal antibody that targets the negative immune checkpoint human VISTA (V-domain Ig suppressor of T cell activation). It indirectly promotes T cells' immune responses by inhibiting VISTA-expressing immunosuppressive cells such as MDSCs (Myeloid-Derived Suppressor Cells) which suppress T cell inactivation and ...
Manufactured by:Exscientia based inOxford, UNITED KINGDOM
EXS21546 is our peripherally-restricted and selective antagonist of the Adenosine A2a Receptor. It is designed for anti-cancer immunotherapy, combatting adenosine related immunosuppressive effects, through T-cell ...
by:Aegle Therapeutics based inWoburn, MASSACHUSETTS (USA)
Advancement of extracellular vesicle therapy to the patient has been hampered by an inability to isolate extracellular vesicles in useful quantities while preserving their structural and functional integrity. EVs derived from MSCs enjoy the same immunosuppressant characteristics of their parent cells. However, when EVs are processed incorrectly, they can trigger an adverse ...
Manufactured by:Operon S.A. based inCuarte de Huerva (Zaragoza), SPAIN
Rotaviruses are one of the main causes of acute gastroenteritis. Gastroenteritis from enteric viruses can be mortal in risk populations such as children, the elderly or immunosuppressed individuals.With an incubation period of 1-3 days, infection is via the fecal-oral route. Characteristic symptoms are vomiting, watery diarrhea at 3-8 days, fever and abdominal pain. Immunization ...
Manufactured by:Kiadis Pharma NV based inAmsterdam, NETHERLANDS
Alomfilimab SAR445256 (formerly KY1044) is a human monoclonal IgG1 that selectively binds to Inducible T cell CO-stimulator (ICOS), a protein expressed at high levels on immunosuppressive regulatory T cells and at lower levels on effector T cells. Alomfilimab is designed to exert anti-tumour activity through preferential depletion of intra-tumoral regulatory T cells and ...
Manufactured by:Boston Pharmaceuticals based inCambridge, MASSACHUSETTS (USA)
BOS-371 is a highly potent monoclonal antibody targeting the Interleukin-1 Receptor Accessory Protein (IL1RAP), a prevalent tumor associated antigen driving tumor growth and immunosuppression. BOS-371 has also been Fc-engineered to enhance effector ...
by:Saneron CCEL Therapeutics, Inc. based inTampa, FLORIDA (USA)
The SERT-CELL program explores the unique potential of Sertoli cells, protein-rich cells found in the mammalian testes, which inhibit immune reactions to foreign tissues, including transplants. Sertoli cells provide localized immunosuppression, which mitigates the need for a patient to undergo costly and potentially dangerous immune suppression, while the therapy is in effect. ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer ...
Manufactured by:Elpiscience based inShanghai, CHINA
ES014 is a first-in-class anti-CD39xTGF-β bispecific antibody (bsAb) that simultaneously targets the adenosine and TGF-β pathways, two major immunosuppressive mechanisms in the tumor microenvironment (TME). Solid tumors frequently express TGF-β, which suppresses T cell activation and induces CD39 expression, the rate-limiting enzyme in the ATP-adenosine pathway. ...
by:Pure Biologics SA based inWroclaw, POLAND
In cancer, a balance between immune system effector and regulatory cells becomes disturbed. Regulatory T cells inhibit the activity of effector cells, including NK cells, a process known as immunosuppression. The PB003 (PureActivator) project embraces a novel approach, aiming to develop a drug based on a bimodal fusion protein, which synergistically activates NK cells and ...
Manufactured by:Porkka Finland based inHOLLOLA, FINLAND
The ice cubes are produced using a spray system that minimizes water and power consumption, resulting in clear and hard ice cubes ideal for patient comfort, particularly for immunosuppressed individuals. The ice flakes are generated in a cylinder with a crushing screw, ensuring the production of dry, loose ice flakes that are easy to handle and store over long periods. These ...
Manufactured by:Universal Cells Inc. based inSeattle, WASHINGTON (USA)
PSC-derived cells that have not been engineered to avoid allogeneic rejection will be eliminated soon after transplantation unless they are HLA-matched to their recipients, delivered to immune privileged sites, or administered along with potentially dangerous ...
Manufactured by:ELITechGroup based inPuteaux, FRANCE
PCP a major cause of morbidity and mortality among HIV-infected patient, nowadays reduced with ART, moreover, represents a significant cause of increasing mortality among HIV-negative patients who are immunosuppressed. For non-immunosuppressed individuals fungal invasion usually leads to asymptomatic colonization. Without treatment, PCP can cause death. Prompt ...
by:Caribou Biosciences, Inc. based inBerkeley, CALIFORNIA (USA)
We are able to differentiate NK cells from induced pluripotent stem cells (iPSCs) that we edit in multiple ways to address targeting, trafficking, proliferation, and overcoming the immunosuppressive tumor microenvironment. ...
Manufactured by:Athelas Incorporated based inMountain View, CALIFORNIA (USA)
This FDA-cleared device helps simplify and enhance the blood monitoring process for those prescribed clozapine and other immunosuppressed patients. Getting a simple, onsite finger-prick is easy, eliminates the need for a venous draw, and the device returns neutrophil and white blood cell count within minutes. ...