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ELANE, or neutrophil elastase (NE), is a serine protease stored in the azurophilic granules of neutrophils and is encoded by the ELANE gene on chromosome 19. It plays a pivotal role in the host defense system by degrading bacterial proteins, remodeling extracellular matrices, and shaping inflammatory responses. However, the same proteolytic activity that protects against pathogens can, when ...
National No Smoking Day is observed in the UK annually on the second Wednesday of March, falling on the 12th of March 2025. Inaugurated on Ash Wednesday in 1984, the day aims to raise awareness of the dangers of smoking and encourage smokers to quit, highlighting the benefits of a smoke-free life. Smoking poses serious health risks, affecting nearly every organ in the body. Smokers significantly ...
Elastase is a powerful enzyme that plays a critical role in various biological processes, both in physiological and pathological contexts. It belongs to the family of serine proteases, which are enzymes characterized by a unique serine residue in their active site. This enzyme is known for its ability to degrade elastin, a key protein that provides elasticity and resilience to tissues such as ...
Ms Jonna Nielsen has smoked most of her life – and continues to do so though diagnosed with COPD years ago. The 48-year-old Danish single mother still wants to stop smoking but no longer thinks of herself as a COPD patient, while the severe coughing spells and derived muscle pain have gradually disappeared in the course of six months. The turning point was a visit to the ...
For a long time, the Dane Jonna Nielsen has had problems with both allergies and COPD, but being presented for a Danish- produced air purifier at the hair dresser changed her life. Now she feels like a whole new ...
The field of medical science has long utilized disease models, which are systems simulating the progression and expression of a disease, to better understand various illnesses. These models facilitate the study of disease pathology, identifying underlying mechanisms, and developing potential treatments. In the context of respiratory diseases, numerous models have been developed, with a prominent ...
The field of medical science has long utilized disease models, which are systems simulating the progression and expression of a disease, to better understand various illnesses. These models facilitate the study of disease pathology, identifying underlying mechanisms, and developing potential treatments. In the context of respiratory diseases, numerous models have been developed, with a prominent ...
Heart failure affects about 6.2 million Americans and is rising in prevalence. With half of these cases presenting as heart failure with preserved ejection fraction (HFpEF), it’s essential for both the medical community and the population at large to have a better understanding of its pathology. [1,2] Knowing the differences between HFpEF and its counterpart, heart failure with reduced ...
Healing rate: 14.3 mm2/day. Healing time: 103 days. Wound size: 49 × 30 × 3 mm. Age of wound when treatment started: ~ 3 months. Subject: 62/male. Non-insulin dependent diabetes, venous insufficiency, peripheral neuropathy, HTN, CHF, COPD, ...
Dental Problems Linked To Heart Disease and Diabetes Over the last ten years there has been a growing body of evidence linking periodontal disease and systemic diseases. Every day new research is making the link stronger. Periodontal infection is the advanced stages of gum disease that causes bone loss. The bone loss is irreversible. Gingivitis is the early stage of gum disease and with early ...
Objective To investigate the rehabilitation value of respiratory neuromuscular Electrical Stimulation. In Pulmonary Rehabilitation of COPD patients. Method 126 patients (85 males and 41 females) with stable Grade-D CODP to GOLD2017 guideline were involved in the RCT study. All cases were divided into stimulation group(n=63) and Control Group(n=63). All patients were given oxygen therapy, ...
Most of us have experienced those frustrating nights, endlessly tossing and turning, unable to nod off. The goal of a good, restful night’s sleep can seem very distant. So often we bring all our daytime stress and anxieties into bed with us. Clearly, anything that can help us unwind, de-stress and get more of that precious shuteye would be a boon. The ancient traditions and practices of ...
By now, you are likely aware of many of the well-established risks associated with smoking cigarettes, such as cancer, asthma, chronic obstructive pulmonary disease (COPD), diabetes, cardiovascular disease, and stroke. But did you know that research has discovered a link between smoking and cognitive decline? This research emphasizes the importance of identifying and controlling modifiable risk ...
There’s an island in northern Lake Michigan called Beaver Island. It sits roughly 30 miles offshore of Michigan’s Lower Peninsula, part of an archipelago of other whimsically named islands (including Whiskey, Hog, Garden, and Hat). Roughly 500 hardy souls call Beaver Island home year-round, and the two townships that occupy the land support a small but stable economy that embodies the ...
The Non-Intrusive LuCED Test for Detection of Early-Stage Lung Cancer: A Subgroup Analysis for Chronic Obstructive Pulmonary Disease (COPD) Introduction VisionGate’s LuCED® test for lung cancer measures 934 features in each cell imaged in 3D by the Cell- CT™. Sensitivity and specificity, both exceeding 90%, have been reported (Wilbur, et. al., Cancer Cytopathology, ...
At the beginning of Chinese New Year, Beijing Yaguo Technology Co., Ltd.'s innovative medical device "Respiratory Power" respiratory neuromuscular stimulator was officially launched. "Respiratory power" has been established in 2015 as a core innovative product of Yaguo, Through 4 years of continuously efforts, after research, demonstration, design, development, and clinical registration it has ...
Is Office Environment Related To Office Illnesses? Everyone is sick but do they all have the same symptoms? Headaches, flu, itchy skin, sore throats, asthma, COPD, cancer, appendicitis! That’s very important! It’s unlikely if the symptoms are different. If everyone has sore throats or upper respiratory irritation then it may be the building such as low humidity. Usually, the symptoms ...
This case study discusses hospital readmissions and provides healthcare professionals with recommended medical algorithms in the form of scores, models, and calculators that can aid in reducing readmissions, especially when related to antibiotic resistant microbiological pathogens. When health analytics, such as the CDC antibiotic resistance program and other algorithms are integrated into ...
Immunomodulation promises to be an effective prophylactic and therapeutic modality for chronic and recurrent respiratory infections. As opposed to vaccines, the term Immunostimulant (IS) refers to a compound that produces a state of non-specific immunity. Most IS are oral formulations of bacterial lysates that have been used in clinical practice for decades. One of the main obstacles in the ...
The burden of Respiratory Tract Infections (RTIs) in children and adults is very high, especially in developing countries. At least 1.9 million children throughout the world died from acute RTIs in 2000, 70% of them in Africa and Southeast Asia. As causative therapies of these frequently recurring infections have substantial limits, preventive measures deserve priority. Among these, non-specific ...