Cytotoxic Articles & Analysis
94 articles found
A single missing fucose residue can enhance antibody-dependent cellular cytotoxicity by 50-fold, revolutionizing cancer immunotherapy approaches. ...
The unique properties of platelets including easy acquisition and strong targeting capabilities together with convenient release options and long circulation times make them ideal drug delivery carriers with weak cytotoxicity and high biosafety which enables their development into effective drug delivery systems. ...
These innovative therapeutic agents combine the targeting capabilities of antibodies with the cytotoxic effects of radioactive isotopes, providing a powerful strategy for precision cancer treatment. ...
Linker Optimization: The linker serves a crucial function in maintaining stability, controlling drug release, and ensuring effective delivery of the cytotoxic drug. Linkers can be cleavable or non-cleavable, each with unique advantages and challenges. ...
Most of the old drugs are currently limited in their effectiveness because of poor pharmacokinetics, simple clearance by the body and cytotoxicity. Nanoparticle technology in particular, Nano drug delivery system is getting a lot of attention and application in medicine in the recent years. ...
These receptors play a key role in regulating immune responses, mediating antibody-dependent cellular cytotoxicity (ADCC) reactions, and antibody-dependent cell phagocytosis (ADCP) processes. ...
ADCs combine the specificity of monoclonal antibodies with the destructive capabilities of cytotoxic drugs, enabling targeted delivery of chemotherapy directly to cancer cells while sparing healthy tissues. The customization aspect of ADCs development allows for the tailoring of both the antibody component and the cytotoxic agent, maximizing efficacy against ...
Traditional serum-based culture methods can introduce variability and unwanted effects due to the complex composition of serum, which may contain cytotoxic substances. To address this, researchers often use serum-free media supplemented with specific cytokines, such as EPO, nerve growth factor (NGF), platelet-derived growth factor (PDGF), and EGF, to support optimal cell growth ...
Toxicology and Drug Development: HCEC-12 cells are often utilized to evaluate the cytotoxic effects of various compounds on corneal epithelium. This application is fundamental in the development of ophthalmic drugs and ensuring their safety for clinical use. ...
In addition, all of these media undergo extensive quality control testing, and each batch is routinely tested for growth promotion, absence of cytotoxicity, and physical parameters such as osmolarity and pH. The complexity of cell culture media composition presents many challenges in optimizing the individual components of the media. ...
Analyzing the efficiency and conditions (such as pH value, enzymatic action, etc.) of its release mechanism is essential for optimizing ADC design and improving its efficacy.3. Determine Cytotoxicity and EfficacyEvaluating the toxicity and killing effects of ADC on target cancer cells through in vitro and in vivo models is a key step in verifying its efficacy. ...
Antibody-drug conjugates (ADCs) represent a groundbreaking class of therapeutics that combine the specificity of monoclonal antibodies (mAbs) with the potent cytotoxic effects of small-molecule drugs. This synergistic approach allows for targeted delivery of the cytotoxic agent to cancer cells while sparing healthy tissues, thereby reducing side effects and ...
Once the TCR binds to the antigen, the T cell initiates an immune response, generating cytotoxic effects, secreting cytokines, and coordinating the activities of other immune cells.There are millions of different T cells in the human body, each with a different TCR. ...
For instance, specific structures of glycans can enhance or weaken the cytotoxicity of antibodies.2. Impact on Stability and DistributionGlycosylation significantly affects the distribution, stability, and clearance rate of drugs in the body.3. ...
Biological Functional Activity Testing(1) Cell Proliferation Inhibition AssayUsed to test whether the antibody drug can inhibit the proliferation of target cells.(2) Cytotoxicity AssaysSuch as Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement-Dependent Cytotoxicity (CDC).(3) Neutralization AssaysFor example, for antibodies ...
Systemic toxicityWe conduct tests on mice to detect medical devices that may produce systemic (but not local) toxic effects. Cytotoxicity of cellsThis test is mainly used to detect cell-damaging substances in medical devices, thereby assessing the toxicity or potential irritation of medical devices. ...
For illustration, functional surface modification of dendrimers is one way to address cytotoxicity. Dendrimers can be designed with specific structures and functionalities that allow precise control of their properties, such as size, shape, solubility, and stability. ...
In vitro studies involve using cell cultures to test the drug release and cytotoxicity, while in vivo studies involve animal models to assess the biodistribution, pharmacokinetics, and therapeutic outcomes. ...
According to their functions in the immune response, T lymphocytes mainly include helper T cells (Th cells), regulatory T cells (Treg cells), effector T cells and cytotoxic T cells. Th cells are common precursors of all Th cell subpopulations before they are stimulated by antigen and are called Th precursor cells with multidirectional differentiation ability. ...
ADCs are complex molecules composed of an antibody linked to a biologically active cytotoxic or radioactive compound. They combine the specificity of antibodies, which enables specific target cell binding, and the cell-killing activity of cytotoxic drugs, providing a method of delivering these agents directly to cancer cells. ...