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Cytotoxic Services
37 services found
by:STEMart based inShirley, CALIFORNIA (USA)
Cytotoxicity testing is a sensitive method to assess the biocompatibility of a material extracted through a specific cell culture media following exposure of the extracted fluid to L929 cells. This test is performed on raw materials in the manufacturing process, all medical devices contacting patients, and devices undergoing a sterilization validation. ...
Manufactured by:AAT Bioquest, Inc. based inPleasanton, CALIFORNIA (USA)
Cell based assays offer a biologically relevant substitute to predict the response of a drug on an organism and while initially used mostly for secondary screening, are now progressively being used for primary screens. AAT Bioquest offers a broad spectrum of cell-based assays for cell cytotoxicity, cell proliferation, GPCR and ion channels. Keywords: primary/secondary screening, ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Antibody-drug conjugates employ the specific monoclonal antibodies (mAbs) to achieve targeted delivery of the conjugated cytotoxic molecules to tumor cells. This delicate design increases the payload efficacy against tumor cells and in the meantime, reduces the cytotoxicity of the otherwise highly toxic payload to normal tissues comparing to traditional ...
by:Biointron based inShanghai, CHINA
Bispecific antibodies can target two different antigens at the same time, such as simultaneously binding tumor cell receptors and recruiting cytotoxic immune cells. BioIntron has expressed thousands bispecific antibodies in 2020 with extensive experience in bispecific antibody production. BioIntron can perform any format bispecific antibody production requested by our client. ...
Manufactured by:MuseChem based inPaoli, PENNSYLVANIA (USA)
Antibody-drug conjugates (ADCs) are a new class of highly potent oncology therapeutics for the treatment of people with cancer. An ADC could be divided into three main structural units: the antibody; the cytotoxic agent (drug); and the linker. The antibody has high affinity for a tumor-associated antigen that has restricted or no expression on normal cells. By combining this ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
As one major component of an antibody-drug conjugate (ADC), the antibody is the key for target specificity and serves as the cargo to deliver the cytotoxic drug (payload). A payload drug can be attached to different sites on an antibody using diverse conjugation chemistry. Multiple endogenous amino acids can serve as potential conjugation sites. However, to achieve more precisely ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
As one major component of an antibody-drug conjugate (ADC), the antibody is the key for target specificity and serves as the cargo to deliver the cytotoxic drug (payload). A payload drug can be attached to different sites on an antibody using diverse conjugation chemistry. Multiple endogenous amino acids can serve as potential conjugation sites. However, to achieve more precisely ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
As one major component of an antibody-drug conjugate (ADC), the antibody is the key for target specificity and serves as the cargo to deliver the cytotoxic drug (payload). A payload drug can be attached to different sites on an antibody using diverse conjugation chemistry. Multiple endogenous amino acids can serve as potential conjugation sites. However, to achieve more precisely ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Fluorouracil is a white to nearly white crystalline powder that is sparingly soluble in water and alcohol. The chemical name of it is 5-fluoro-2,4(1H,3H)-pyrimidinedione. Fluorouracil is a cytotoxic chemoradiotherapy medication used to treat rectal cancer, head and neck cancer, esophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer by intravenous ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Cell lines are an important research tool, often used in place of primary cells and intact organisms to study biological processes. Cell lines have long been used for a variety of applications such as testing drug metabolism and cytotoxicity, gene function studies, generation of artificial tissues, and synthesis of biological compounds. LK 2 Cell ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Cell lines are an important research tool, often used in place of primary cells and intact organisms to study biological processes. Cell lines have long been used for a variety of applications such as testing drug metabolism and cytotoxicity, gene function studies, generation of artificial tissues, and synthesis of biological compounds. LU99 Cell ...
Manufactured by:Sanquin based inAmsterdam, NETHERLANDS
Our proprietary technology for UV-induced MHC-peptide exchange is ideally suited for high-throughput screening of peptide-binding to the MHC class I complexes. Moreover, combinatorial coding enables fast finding of relevant peptide-specific cytotoxic T ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Cell lines are an important research tool, often used in place of primary cells and intact organisms to study biological processes. Cell lines have long been used for a variety of applications such as testing drug metabolism and cytotoxicity, gene function studies, generation of artificial tissues, and synthesis of biological compounds. The C106 cell line was established from a ...
by:Revvity Gene Delivery (formerly SIRION Biotech) based inHamburg, GERMANY
In the discovery of oncology therapeutics, Antibody-drug conjugates (ADCs) are rapidly gaining momentum, with hundreds of candidates advancing through clinical development. Whether your priority lies in assessing the epitope binding of your construct, evaluating the cytotoxic potency of the payload, or scrutinizing the efficacy of the linker in cleaving, each facet demands ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
One of the main obstacles in drug development is how to deliver drugs effectively to target cells. In general, macromolecules such as proteins and mRNA cannot penetrate the cell membrane because the cell membrane has acquired protective mechanisms through evolution. However, viruses can deliver their genetic material into cells. Therefore, viruses and virus-like particles are widely used to ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains. Compared to αβ T cells, γδ T cells without MHC restriction on tumor antigen recognition have strong cytotoxic effects on tumor cells. γδ T cells have been considered as wonderful effector cells for cancer immunotherapy. Creative Biolabs is an excellent expert in γδ T cell research ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Apoptosis is pivotal in immune responses, involving processes such as intracellular balance, T cell clustering, the death of reactive lymphocytes, and cytotoxity of target cells. Apoptosis involves key components like APO-1/Fas, a receptor essential for apoptotic signaling; Caspase-3, crucial for apoptosis and osteoclast activation; and CD30, whose activation halts cell growth ...
Manufactured by:Invicro, LLC based inNeedham, MASSACHUSETTS (USA)
Radiopharmaceutical therapies represent an effective way to treat solid cancers by using tumor targeting small molecules, peptides or biologics to deliver a cytotoxic payload that induces DNA damage in tumor cells, while limiting damage to normal and healthy tissue. Streamlined development, evaluation and clinical translation of radiopharmaceuticals requires a partner that has ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Tumor immunotherapy utilizes active or passive methods to provoke tumor-specific immune responses in the body, harnessing their inhibitory and cytotoxic functions against tumor cells. Characterized by its specificity, efficacy, and mitigation of collateral damage, immunotherapy distinguishes itself from conventional methods such as surgery, targeted therapy, and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Antibodies facilitate immunity by inhibiting critical stages of a pathogen's replication cycle, such as receptor binding and cellular entry, activating the complement system, or initiating specific cell-mediated immune response, such as antibody-dependent cellular cytotoxicity. ...