Cytotoxic Articles & Analysis
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The premium transfection reagents from Amerigo Scientific are well-known for high effectiveness, minimal cytotoxicity, and versatility across a wide array of cell lines. As these reagents are engineered to optimize the cellular uptake of DNA, RNA, siRNA, and various types of nucleotides, researchers can obtain reliable transfection results with little effort. ...
BS-100-EF) are ideal for sensitive applications where minimal levels of contaminants are required, such as cytotoxicity studies, immunological studies and sterility testing. These nanoparticles are also well suited for conjugate development for blotting and electron microscopy applications. ...
These sophisticated compounds elegantly bind monoclonal antibodies to cytotoxic agents via linkers, targeting specific antigens while minimizing systematic exposure. This technique combines the selectivity of antibodies with the potency of cytotoxic drugs, allowing for a highly focused approach to disease management, especially in oncology research. ...
Introduction Intraoperative irrigation is a commonly used method aimed at reducing microbial burden by removing tissue debris, metabolic waste, and tissue exudate from the surgical field prior to site closure.1 With the absence of universally established standard of care and robust clinical data, the selection of appropriate irrigation solution remains a topic of debate. Isotonic saline has ...
Protheragen-ING Lab's expert team of scientists and technicians are experienced in conducting a wide range of safety tests, including biocompatibility, cytotoxicity, genotoxicity, and hemocompatibility testing, among others. ...
This reagent has become increasingly popular in bioorthogonal chemistry, particularly in the field of antibody-drug conjugates (ADCs), a promising class of therapeutics that combines the targeting ability of antibodies with the potency of cytotoxic drugs. Tetrazines, on the other hand, serve as highly reactive dienophiles in inverse-electron demand Diels-Alder reactions with ...
Notable PEGs include mPEG36-NH2, NH2-PEG24-COOH, OH-PEG9-OH, mPEG8-SPA, and more.ADCs represent a cutting-edge approach to cancer treatment, combining the specificity of monoclonal antibodies with the potency of cytotoxic drugs. The choice of linker molecules plays a crucial role in determining the overall success of ADCs. ...
In collaboration with renowned research institutions, CD Formulation has created an in vitro cytotoxicity testing platform specifically designed for microspheres and microneedles. ...
” Tevogen Bio is a clinical-stage specialty immunotherapy company harnessing one of nature’s most powerful immunological weapons, CD8+ cytotoxic T lymphocytes, to develop off-the-shelf, precision T cell therapies for the treatment of infectious diseases, cancers, and neurological disorders with the aim of addressing the significant unmet needs of large patient ...
In addition to microsphere mass production, CD Formulation has expanded its expertise to include analytical testing, formulation development, stability testing, in vitro cytotoxicity testing, and ...
Microspheres & Microneedles In Vitro Release TestingThe microsphere and microneedle in vitro release test provided by CD Formulation is to test and evaluate the release amount and release rate of the drug within a certain period of time after administration, and to investigate the release behavior of the drug carrier. In Vitro Cytotoxicity Testing for Microspheres & ...
The featured vaccine products supplied by Alfa Chemistry are listed as below: Nucleic Acid Delivery ExcipientsNucleotide vaccines, including mRNA vaccines with their intracellular antigen synthesis, have been shown to be potent activators of a cytotoxic immune response. However, the intracellular delivery of mRNA vaccines to the cytosol of antigen presenting immune cells remains ...
I am confident that our unique approach in identifying and selecting antigens that could elicit broader cytotoxic T cell and antibody responses is well positioned to help create broadly protective betacoronavirus vaccines that could protect the global population against multiple betacoronavirus threats on a long-term ...
“There is a clear unmet need in metastatic endometrial cancer for a therapeutic option after primary or secondary chemotherapy treatment that can meaningfully delay disease progression without debilitating side effects prior to the next round of cytotoxic therapy,” said Lehr. “We believe that dual targeting of both the progesterone receptor and estrogen receptor ...
FDA-approved fusion proteins to date are used as agonists of receptor function, such as romiplostim and alefacept; as antagonists that block receptor function, such as etanercept, belatacept, abatacept, lilocept, and aflibercept; or as a direct cytotoxic agent, such as denileukin-diftitox. Meanwhile, a large number of potential candidate peptides targeting the metabolic, ...
LB-100 has potential widespread use as an anti-cancer agent when used alone and in combination with standard anti-cancer therapies, including cytotoxic drugs, radiation, and immune checkpoint blockers. To view LIXTE Biotechnology Holdings' presentation at the Planet MicroCap conference, register in advance at: https://planetmicrocapshowcase.com/signup The Planet MicroCap ...
The expanded CORE-NK cells exhibit enhanced cytotoxicity, metabolism, and expression of activating receptors compared to fresh, activated NK cells. ...
The expanded CORE-NK cells exhibit enhanced cytotoxicity, metabolism, and expression of activating receptors compared to fresh, activated NK cells. ...
This further expands the GlycoConnect™ ADC tool kit by significantly enhancing the versatility across cytotoxic payloads and supports further expansion into antibody-based targeted gene therapy and immune cell engager ...
Doxorubicin alone has been the cornerstone of first line treatment of ASTS for over 40 years, with little therapeutic gain from adding cytotoxic compounds to or substituting other cytotoxic compounds for doxorubicin. ...