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Crispr Equipment & Supplies
43 equipment items found
Manufactured by:Integrated DNA Technologies, Inc. based inCoralville, IOWA (USA)
The Alt-R CRISPR-Cas9 System includes all of the reagents needed for successful genome editing based on the natural S. pyogenes CRISPR-Cas9 system. Discover what makes the Alt-R CRISPR-Cas9 system best in ...
Manufactured by:BioVision, Inc., based inMilpitas, CALIFORNIA (USA)
Cas9 (CRISPR associated protein 9) is an RNA-guided DNA endonuclease enzyme associated with the CRISPR (Clustered Regularly Interspersed Palindromic Repeats) adaptive immunity system in Streptococcus pyogenes and other bacteria. Cas9 is used to interrogate and cleave foreign DNA, such as invading bacteriophage DNA or plasmid DNA. ...
Manufactured by:Cellomics Technology, LLC based inHalethorpe, MARYLAND (USA)
CISH (Cytokine Inducible SH2 Containing Protein) contains a SH2 domain and a SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CISH may be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent ...
Manufactured by:Cellomics Technology, LLC based inHalethorpe, MARYLAND (USA)
eSpCas9 (enhanced specificity Cas9) has enhanced specificity compared to wild type Cas9 for CRISPR/Cas9 genome editing. eSpCas9 is able to reduce off-target effects and maintain robust on-target genome editing efficiency, allowing more efficient gene targeting. eSpCas9 (CAG, Neo) lentivirus expresses eSpCas9 under the control of the CAG promoter with neomycin as a selection ...
Manufactured by:Aldevron, LLC based inFargo, NORTH DAKOTA (USA)
A simple solution from R&D to clinical material. Aldevron provides research grade Cas9 nucleases for use in development work as well as standard GMP products for clinical studies. The concentration for these products is 10 mg/mL, dispensed in the following sizes: Research Grade: 0.25 mg and 5 mg vials. GMP: 10 mg and 50 mg ...
Manufactured by:SBI System Biosciences, LLC based inPalo Alto, CALIFORNIA (USA)
Use this first-generation SBI EF1α-hspCas9 SmartNickase when you want to reduce off-target events, have transfectable cells, and prefer an intact vector. Conveniently deliver Cas9 Nickase and gRNA with a single vector. Reduce off-target activity. Drive Cas9 Nickase expression with the EF1α promoter, which provides medium expression levels in most cell types, including primary cells ...
Manufactured by:SBI System Biosciences, LLC based inPalo Alto, CALIFORNIA (USA)
Easily verify transfection efficiencies with this All-in-one Cas9 SmartNuclease Plasmid that coordinately expresses RFP- EF1α-T7-hspCas9-T2A-RFP-H1-gRNA. Conveniently deliver Cas9 and gRNA with a single vector. Monitor transfection efficiencies with RFP, which is coordinately expressed with the hspCas9 gene via the T2A element. Drive Cas9 expression with the EF1α promoter, which ...
Manufactured by:Locus Biosciences, Inc. based inMorrisville, NORTH CAROLINA (USA)
Locus is the world’s leading developer of products based on CRISPR-Cas3 systems. CRISPR evolved as a bacterial immune system, which protects bacterial cells from invading viruses. Cas3 is a powerful exonuclease that shreds the DNA of targeted bacterial cells beyond repair, leading to rapid and predictable cell death. ...
by:Intellia Therapeutics, Inc. based inCambridge, MASSACHUSETTS (USA)
Genome editing is efficient, precise and scalable. CRISPR/Cas9 genome editing can make permanent, precisely targeted changes in patients’ chromosomes and repair the underlying genetic mutation, whereas more traditional gene therapy typically involves introducing a non-permanent copy of a gene into patients’ cells. These attributes of CRISPR/Cas9 ...
Manufactured by:Agilent Technologies, Inc. based inSanta Clara, CALIFORNIA (USA)
The SureGuide gRNA Synthesis Kit is part of an integrated solution for in-vitro CRISPR/Cas research. Use this kit to generate high concentrations of gRNA, and combine with the SureGuide Cas9, or your own Cas9 protein, to clone complex genomic regions with high accuracy and specificity. The SureGuide gRNA kit shortens your time from planning to experiment, and reduces the cost of ...
by:Intellia Therapeutics, Inc. based inCambridge, MASSACHUSETTS (USA)
We plan to initiate patient screening for a first-in-human Phase 1 study of NTLA-5001, a WT1-directed TCR T cell therapy for the treatment of AML, by the end of 2021. Our first ex vivo development candidate seeks to treat acute myeloid leukemia (AML) by engineering autologous T cell receptors (TCR) directed towards the Wilms’ Tumor 1 (WT1) antigen, an over-expressed protein that is often ...
by:Caribou Biosciences, Inc. based inBerkeley, CALIFORNIA (USA)
Our chRDNA technology enables multiple genome edits, including multiplex gene insertions, with a high degree of specificity and lower levels of off-target editing than first generation CRISPR-Cas9. ...
Manufactured by:Locus Biosciences, Inc. based inMorrisville, NORTH CAROLINA (USA)
CRISPR-Cas3 offers a unique approach to human genome editing with the ability to produce long-range deletions. Our IP portfolio enables the use of Cas3 human gene editing, a capability that we have been incubating since the inception of Locus. ...
Manufactured by:10x Genomics based inPleasanton, PENNSYLVANIA (USA)
Explore cellular heterogeneity, novel targets, and biomarkers with combined gene expression, surface protein expression, or CRISPR edits in each ...
Manufactured by:ASC Therapeutics based inMilpitas, CALIFORNIA (USA)
As a therapeutic modality, genome editing can correct a defective gene, disrupt a deleterious gene, or target a therapeutic gene to a precise location in the genome for safe and optimal expression of the therapeutic protein. We are applying the optimized CRISPR-Cas9 and in-house-developed TARGATT™ gene editing technologies for therapeutic development, focusing on improving ...
Manufactured by:Mammoth Biosciences, Inc. based inBrisbane, CALIFORNIA (USA)
A CRISPR-based detection solution for SARS-CoV-2. Mammoth Biosciences has developed a turnkey workstation to run a CRISPR-based SARS-CoV-2 molecular assay based on automated liquid handling equipment. This high throughput system can perform thousands of tests per day with minimal user interaction. ...
Manufactured by:Evox Therapeutics Limited based inOxford, UNITED KINGDOM
Targeted drug delivery has a role to play in the delivery of many if not all drugs, but targeted delivery systems are critical for the delivery of nucleic acid-based agents such as siRNA and CRISPR-Cas ...
Manufactured by:Agilent Technologies, Inc. based inSanta Clara, CALIFORNIA (USA)
The Cas9 endonuclease kit is part of an integrated solution for in-vitro CRISPR/Cas resesarch. Use this kit for in-vitro cloning of large genes or DNA fragments without the limitations imposed by common restriction enzymes or PCR fidelity. Allows cleavage of DNA at single and multiple locations based on a custom sequence of interest. ...
Manufactured by:Thermo Fisher Scientific based inWaltham, MASSACHUSETTS (USA)
Invitrogen TrueCut HiFi Cas9 Protein is a high fidelity CRISPR Cas9 protein variant engineered to demonstrate superior off-target profiles, while preserving maximum on-target editing efficiency. TrueCut HiFi Cas9 Protein is ideal for applications that are sensitive to off-target events and when more precise editing is ...
Manufactured by:BTX - Harvard Bioscience, Inc. based inHolliston, MASSACHUSETTS (USA)
The ECM 830 is a versatile electroporation system suitable for applications for gene, drug and protein delivery including: CRISPR, mammalian cells, in vivo, ex vivo, in ovo tissue, ex plant and nuclear ...