Clinical Phase Articles & Analysis
42 articles found
By focusing on streamlining the CAR-T development process, Alfa Cytology enables faster and more effective translation of laboratory research into viable clinical treatments. The preclinical phase is critical for identifying the potential efficacy and safety of CAR-T therapies before moving to human trials, and Alfa Cytology's approach is designed to optimize ...
Only 10% of drugs advanced to the clinical stage are successfully brought to market, with half of all failures attributed to lack of clinical efficacy. This means that approximately $60 billion dollars are spent annually on unsuccessful drugs.1,2 Contributing to these unchecked costs - and the complexity of drug discovery and development - is the fact that the ...
In vitro DMPK services, along with absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies, play a vital role in predicting pharmacokinetic properties and potential adverse effects of drugs before they reach the clinical testing phase. In vitro DMPK services provide an array of tests that simulate the human body's response to a drug. ...
In vitro DMPK services, along with absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies, play a vital role in predicting pharmacokinetic properties and potential adverse effects of drugs before they reach the clinical testing phase. In vitro DMPK services provide an array of tests that simulate the human body's response to a drug. ...
With zapnometinib’s favorable outcome in a recent phase II clinical trial in hospitalized COVID-19 patients, the present results are even more promising for an upcoming phase II clinical trial in severe influenza virus infection. 1 Introduction As of today, virus infections, especially those with pandemic potential, ...
It also has a strong competitor, Enhertu, in the approved breast cancer field. For example, in the ASCENT clinical trial, 9% of patients experienced rash and 5% of patients experienced eye toxicity. ...
These models can be used to study disease progression, test drug candidates, and gain insights into drug mechanisms of action. In the clinical development phase, single-cell RNA sequencing has the potential to inform decision-making in several ways. ...
Nearly 100 recombinant vaccine candidates are currently in Phase I clinical development, currently the largest number of all types. ...
These models facilitate the study of disease progression, testing of drug candidates, and gaining insights into drug mechanisms of action. During the clinical development phase, scRNA-seq informs decision-making in several ways. ...
The Development Trend of PROTAC Verify the degradation of "non-druggable proteins" in clinical trials: At present, PROTAC molecules that have entered the clinical trial stage mainly target traditional AR, ER, BTK, etc. Kymera Therapeutics’ KT-333 targeting STAT3 and Astellas Pharma’s ASP3082 targeting KRAS G12D are in phase I ...
Most of these products are in early stage of development against SARS-CoV-2, but already have acquired clinical data (mostly phase 1 or 2) in other indications. One of the major challenges is the manufacturing of a new SARS-CoV-2 vaccine in large scale for global demand. ...
ByNuvonis
We recently announced a Statistically Significant Reduction of Seizures for Epilepsy Compared to Standard CBD from a Clinical Dose & Efficacy Study ("Study'') conducted by Dr. W McIntyre Burnham, with the Ontario Brain Institute and emeritus professor of the University of Toronto's Temerty Faculty of Medicine. ...
At present, the Vetex thrombectomy catheter is in the early clinical trial phase. Vetex Medical plans to seek FDA 510(k) clearance for the device. ...
For the more than 6 million individuals living with Alzheimer’s disease in the US, their families, and their caretakers, our team at Altoida celebrates the positive topline data reported on the CLARITY AD global Phase 3 clinical trial of Eisai and Biogen’s Lecanemab. The theme of World Alzheimer’s Awareness Month, which is every September, is ...
Futura Medical has announced positive results from a clinical trial looking into MED3000, a topical gel formulation for the treatment of erectile dysfunction (ED). The results, from the confirmatory phase 3 clinical study, FM71, were announced today (August 31). MED3000 is a breakthrough, fast-acting gel produced by Futura Medical’s ...
Alzheimer's disease (AD) is a progressive, irreversible neurodegenerative disease clinically manifested by cognitive impairment, behavioral abnormalities, and social deficits. ...
The study will evaluate subjects’ ability to raise mucosal antibodies in the nasal passages, serum antibodies against matched and drifted strains of the influenza virus, and cellular immune responses. In a prior Phase 2 drifted H3N2 challenge trial, M2SR demonstrated efficacy against infection and illness across seven years of flu virus drift. ...
The comprehensive cancer center designation means patients can access treatments exclusive to Karmanos, as well as clinical trials, cancer prevention programs, and multidisciplinary teams of cancer specialists — a comprehensive approach you cannot find in many large hospitals or health systems. ...
In June 2021, Intellia Therapeutics' NTLA-2001, a CRISPR gene editing therapy for the treatment of transthyretin amyloidosis (ATTR) invented by Nobel Laureate Jennifer Doudna, was proven to be safe and effective in a clinical trial involving six patients. This was the first clinical trial result of an in vivo CRISPR gene editing therapy that has been published. ...
Overall, these findings show that Ensitrelvir, which is an antiviral drug that is currently being tested in Phase II/III clinical trials, has impressive antiviral efficiency and effectiveness against SARS-CoV-2 and could be a viable oral treatment option for COVID-19. ...