Metabolic Pathway Articles & Analysis
50 articles found
Synthetic biology is driving the design of entire metabolic pathways assembled via modular enzymes, allowing for on-demand biosynthesis of complex molecules. ...
Despite these challenges, this field continues to expand, offering increasingly personalized and effective treatments for various malignancies. Cardiovascular and metabolic APIs address some of the most prevalent health challenges globally. ...
Role in Drug Metabolism The role of cytochrome P450 in drug metabolism is two-fold: it can either detoxify drugs or convert them into active metabolites. The metabolic pathways involving CYP enzymes are generally categorized into two phases: Phase I Reactions: These involve the introduction or modification of functional groups on ...
Moreover, S9 assays help in predicting drug-drug interactions. Many drugs are metabolized by the same pathways; thus, understanding the metabolic profile can provide insights into potential interactions that might lead to adverse effects. ...
Biosynthesis: Intermediates of the TCA Cycle serve as precursors for the biosynthesis of amino acids, heme, and other essential biomolecules. Metabolic Flexibility: The cycle can integrate inputs from various metabolic pathways, allowing cells to adapt to changing nutritional states. ...
Various factors contribute to this phenomenon, including genetic mutations, alterations in drug targets, enhanced drug efflux, and changes in metabolic pathways. In cancer, the heterogeneity of tumors often results in a subset of cells that can survive initial treatments, leading to relapse and metastasis. ...
This method allows researchers to map the flow of material (carbon, nitrogen, or other molecules) through different metabolic pathways. By determining the flux of these compounds, scientists can uncover how organisms regulate energy production, biosynthesis, and other critical cellular processes under various conditions. MFA works by combining experimental data ...
Conversely, exosome metabolomics provides valuable information about cellular metabolic reprogramming, particularly in diseases such as cancer, neurodegeneration, and metabolic disorders. ...
NAD and NADH are not merely passive participants in metabolism—they are regulatory molecules that influence key metabolic pathways, including glycolysis, oxidative phosphorylation, and biosynthetic reactions. ...
This capability is instrumental in understanding the genetic basis of traits, discovering new genes, and exploring metabolic pathways. In addition to fundamental research, fosmid libraries are employed in medical and pharmaceutical applications. ...
ADME stands for Absorption, Distribution, Metabolism, and Excretion, which are critical processes that determine the fate of a drug within the body. ...
Not all tumor cells exhibit glycolysis due to different cellular origins and differentiation degrees, and the contribution of glycolysis to the total ATP of tumor cells varies from 1% to 64%. The energy metabolic pathways of different tumors are different. When anti-metabolic drugs are selected to treat tumors, the energy ...
Proteomics: A large-scale study of the proteome, the entire set of proteins expressed by the genome, can identify protein signaling pathways that are disrupted in brain tumors. Proteomic analysis can reveal potential biomarkers for diagnosis and targets for new treatments1. ...
Metabolism plays a key role in the fields of physiology, cell biology and medicine. Disturbances in metabolic pathways can lead to many common human diseases such as cancer, diabetes, obesity, hypoglycemia, hypolipidemia, phenylketonuria, neurodegeneration, etc. ...
In medical science research, it is hoped that analysis to identify abnormal metabolic pathways and characteristic biomarkers closely related to diseases will provide a basis for further elucidation of disease pathogenesis. ...
Through lipid-lipid interactions and interactions between lipids and other biomolecules, a complex network of lipid metabolism is formed, which is involved in a large number of life activities. ...
This process occurs in plants through photosynthesis and in animals through various metabolic pathways. The synthesis of carbohydrates involves a series of enzymatic reactions that convert simple molecules into more complex structures. ...
The most reliable way to detect HP is to use this non-invasive 13C-UBT method, which can infer H. pylori in the stomach by detecting the 13C/12C isotope ratio in the exhaled gas after oral administration of 13C-urea. Drug Metabolism Study The study of drug metabolism in the body is a very critical process for the development of new drugs, and the elements of ...
Uncover Drug Targets: Metabolomics aids in the identification of potential therapeutic targets by highlighting specific metabolites or metabolic pathways that are dysregulated in diseases. This information enables the development of targeted therapies aimed at restoring normal metabolic balance. Understand Biological Pathways: ...
There are multiple metabolic disease models developed to assist in studying these complex disorders. For instance, diet-induced obesity (DIO) models help understand obesity and related metabolic disorders. Similarly, genetically engineered mouse models provide insight into the role of specific genes in metabolic diseases. ...