Metabolic Pathway Articles & Analysis: Older
39 articles found
Not all tumor cells exhibit glycolysis due to different cellular origins and differentiation degrees, and the contribution of glycolysis to the total ATP of tumor cells varies from 1% to 64%. The energy metabolic pathways of different tumors are different. When anti-metabolic drugs are selected to treat tumors, the energy ...
Proteomics: A large-scale study of the proteome, the entire set of proteins expressed by the genome, can identify protein signaling pathways that are disrupted in brain tumors. Proteomic analysis can reveal potential biomarkers for diagnosis and targets for new treatments1. ...
Metabolism plays a key role in the fields of physiology, cell biology and medicine. Disturbances in metabolic pathways can lead to many common human diseases such as cancer, diabetes, obesity, hypoglycemia, hypolipidemia, phenylketonuria, neurodegeneration, etc. ...
In medical science research, it is hoped that analysis to identify abnormal metabolic pathways and characteristic biomarkers closely related to diseases will provide a basis for further elucidation of disease pathogenesis. ...
Through lipid-lipid interactions and interactions between lipids and other biomolecules, a complex network of lipid metabolism is formed, which is involved in a large number of life activities. ...
This process occurs in plants through photosynthesis and in animals through various metabolic pathways. The synthesis of carbohydrates involves a series of enzymatic reactions that convert simple molecules into more complex structures. ...
The most reliable way to detect HP is to use this non-invasive 13C-UBT method, which can infer H. pylori in the stomach by detecting the 13C/12C isotope ratio in the exhaled gas after oral administration of 13C-urea. Drug Metabolism Study The study of drug metabolism in the body is a very critical process for the development of new drugs, and the elements of ...
Uncover Drug Targets: Metabolomics aids in the identification of potential therapeutic targets by highlighting specific metabolites or metabolic pathways that are dysregulated in diseases. This information enables the development of targeted therapies aimed at restoring normal metabolic balance. Understand Biological Pathways: ...
There are multiple metabolic disease models developed to assist in studying these complex disorders. For instance, diet-induced obesity (DIO) models help understand obesity and related metabolic disorders. Similarly, genetically engineered mouse models provide insight into the role of specific genes in metabolic diseases. ...
When the Bateman domain is altered, it affects the ability of AMPK to bind AMP, which in turn affects cellular energy metabolism. AMPK Signaling Pathway Numerous growth factors, altered cellular stress, altered cell motility, and altered energy uptake can all activate AMPK upstream kinases. ...
Host cell proteases play critical roles in catalysis, metabolic pathways, and turnover of extracellular waste, but when present in the cell culture medium, proteases may lead to product breakdown. ...
Inherent Biodegradability Post-drug dispensation, biodegradable microspheres undergo decomposition, aligning with the body’s natural metabolic pathways. This eliminates surgical extractions, mitigating potential complications and bolstering patient comfort. 3. ...
The following steps are included in the genetic engineering process: Target Gene Identification: The first step is to locate the genes that are responsible for the desired attribute using genome sequencing or metabolic pathway research on yeast. Gene Modification: CRISPR-Cas9 or homologous recombination are two genetic engineering methods used to change the ...
AdvaitaBio’s IPathwayGuide plays significant role in the research of a Stanford investigator. Stanford University is one of the world’s leading research and teaching institutions. With a 1.69 billion dollar annual sponsored research budget, Stanford has been delivering breakthrough discoveries in numerous domains. For over 6 years, Dr. Linda Yip has been conducting research at ...
Researches focus on disease-related genes, regulatory and interaction systems, metabolic systems, genetic variation, laboratory diagnosis and specific prevention, drug resistance genes, virulence genes and so on. Specifically, microbial whole genome sequencing can be applied to: · Diagnosis and identification of pathogens · Epidemiological ...
Companies may also explore what happens when inhibiting genes that interact directly with KRAS. These are called metabolic pathways. By contrast, Recursion Pharmaceuticals looks at all genes when studying KRAS-driven cancers. It may discover that genes far away from known metabolic pathways are also active. No other companies ...
Predicting metabolic models in the early stage of drug discovery is of great significance to improve the success rate of drug discovery. ...
This pathway is essential for the proliferation and survival of PDAC cells, so a deep understanding of the regulatory mechanism of this pathway is helpful to provide new ideas and targets for the clinical treatment of PDAC. ...
The human gut microbiota has a large gene pool, encoding approximately 100-150 times more genes than the human genome, and contains a rich resource of enzymes with the ability to metabolize drugs. The diversity of gut bacteria also affects the mental health of the host. ...
Recently, a research paper published in Nat Commun entitled "Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides" specifically studied the enzymatic strategies and metabolic pathways used by dolphins to decompose their microbial symbiotic communities of dietary fiber. ...