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We are on a mission to develop a new era of CNS disorder treatments. Our groundbreaking work aims to modify multiple cognition issues related to Alzheimer’s disease, Parkinson’s disease, diabetic cognitive decline, and a number of other CNS disease ...
Fentanyl is a synthetic opioid related to the phenylpiperidines. Fentanyl is approximately 100 times more potent than morphine. This agent is highly lipid soluble and rapidly cross the blood-brain barrier. This is reflected in the half-life for equilibration between the plasma and cerebrospinal fluid of approximately 5 minutes for fentanyl. The levels in plasma and cerebrospinal fluid decline ...
Brain microvascular endothelial cells (BMEC), the major component of the blood-brain barrier, limit the passage of soluble and cellular substances from the blood into the brain. BMEC have unique features to distinguish themselves from those of peripheral endothelial cells, such as 1) intercellular tight junctions that display high electrical resistance and slow paracellular flux, 2) the absence ...
Collagen is a major component of the human body. About 30% of our total body protein is collagen. Collagen is crucial for mobile joints, stable bones, healthy muscles, strong ligaments and tendons, smooth skin, glossy hair and healthy nails. It is one of the primary structural proteins of connective tissues and also abundant in blood vessels, intervertebral discs, the blood-brain barrier, the ...
Collagen is a major component of the human body. About 30% of our total body protein is collagen. Collagen is crucial for mobile joints, stable bones, healthy muscles, strong ligaments and tendons, smooth skin, glossy hair and healthy finger nails. It is one of the primary structural proteins of connective tissues and also abundant in blood vessels, intervertebral discs, the blood-brain barrier, ...