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Mtoz Biolabs Rss Services Available In In Uruguay
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by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
In the biological activities of organisms, the function of proteins is achieved through interactions between proteins. Therefore, studying new protein interactions can provide new directions for investigating the potential functions of proteins. Among many protein interaction identification experiments, pull-down is commonly used for in vitro protein interaction testing, and helps discover new ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
With ongoing advancements in proteomics mass spectrometry technology, there has been a notable increase in the precision of analytical instruments, resulting in a richer dataset. While this detailed protein data is invaluable for deeper scientific investigation, the vast volumes of data produced by high-throughput proteomic screenings introduce substantial challenges in analyzing protein sample ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Receptors are biomolecules that can bind with hormones, neurotransmitters, drugs, or intracellular signaling molecules and are capable of inducing changes in cellular function. Receptors are categorized based on their cellular location into cell surface receptors and intracellular receptors. Each receptor typically has two active sites: one that recognizes and binds to the ligand and another ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
With the rapid development of biotechnology, drug research and development has gradually entered a new era of precision and personalization. Targeted Protein Degradation (TPD) drugs are an emerging therapeutic strategy that utilizes the body's ubiquitin-proteasome system to degrade specific pathological proteins to achieve precise treatment. As an important new class of therapeutic drugs, TPD ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Humans are highly organized systems comprised of approximately 3.72×1013 cells of various types, which maintain proper organ function and normal cellular homeostasis. Despite significant and revolutionary discoveries in the field of cell biology, the heterogeneity of cells still requires further investigation. Single-cell RNA sequencing (scRNA-seq) has become the latest method for revealing the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs provides bile acids analysis service using UPLC/TripleQuad5500, which can quantitatively analyze over 90 kinds of bile ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Molecular size variation critically influences the properties of biomacromolecules such as proteins, antibodies, and peptides, especially in the realms of drug research and bioproduct manufacturing. Size Exclusion Chromatography (SEC), also known as Gel Permeation Chromatography (GPC), separates compounds based on molecular size. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
During the production of bioproducts, it's common to find impurities not only produced in the manufacturing process but also related to the desired products. These product-related impurities typically consist of product variants that do not align functionally with the target product. The most common variants arise from chemical modifications, as well as from the degradation and aggregation of the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Cell death occurs through several pathways including apoptosis, necrosis, and other emergent pathways. Apoptosis is pivotal in immune responses, involving processes such as intracellular balance, T cell clustering, the death of reactive lymphocytes, and cytotoxity of target cells. Apoptosis involves key components like APO-1/Fas, a receptor essential for apoptotic signaling; Caspase-3, crucial ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Obesity is a systemic disease, not only does it lead to changes in body shape, but it also brings along various diseases and complications, affecting an individual's overall health. Common complications, such as hyperglycemia, hyperlipidemia, and hypertension, are medically termed as "metabolic syndrome". The fluid factors secreted by adipose tissue propel the development of metabolic syndrome ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The gut microbiota, also known as the gut microbiota, refers to the microorganisms that live in the digestive tract of humans and other animals, including bacteria and fungi. In the human body, without gut microbiota, some undigested carbohydrates cannot be consumed because certain types of gut microbiota have enzymes that human cells lack to break down certain polysaccharides. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Different fatty acids (FAs) vary greatly in the number of double bonds and the length of their carbon (C) chains. Very long-chain fatty acids (VLCFAs) are fatty acids with more than 20 carbon atoms. VLCFAs are precursors of lipid mediators and are components of cellular lipids such as sphingolipids and glycerophospholipids. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Polyprenols are long-chain isoprenoid alcohols. The general formula for polyprenols is H-(C5H8)n-OH, where n refers to the number of isoprene units. Polyprenols are classified into three types: all-trans (solanesol-type), two-trans (Solanesol-type) and poly-cis (Betulaprenol-type), and three-trans and poly-cis (Ficaprenol-type). Despite their low content, polyprenols are natural bioregulators ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Polyunsaturated fatty acids (PUFAs) are primarily classified into ω-3 and ω-6 fatty acids. The difference between these two fatty acids lies in the position of the first double bond from the methyl end of the fatty acid chain. ω-6 fatty acids have a carbon-carbon double bond at the n-6 ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Drug screening refers to the evaluated process of substances (samples) potentially used as drugs, assessing their biological activity, pharmacological effects, and therapeutic value through appropriate methods. This process encompasses biochemical and cellular levels of screening, divided into high-throughput screening (HTS) and virtual ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
To accelerate the development of cancer immunotherapy, it is essential to systematically identify tumor antigens that are truly tumor-specific, patient-shared, stably expressed (i. e., cloned) and immunogenic in all malignant cells. Immunopeptidomics is a large-scale and in-depth approach capable of identifying and quantifying the presented human leukocyte antigen (HLA) immunopeptidome. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Antibodies (Abs) are essential components of the adaptive immune system, which can combat infections and other harmful agents. Produced by B cells, Ab is either secreted or expressed on the plasma membrane at the present of B cell receptors (BCRs). Each Ab comprises two heavy chains (VH) and two light chains (VL). The VL each include a constant region varing only across different classes and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The inauguration of monoclonal antibodies (mAbs), derived from mice, were immunogenic in humans. These molecules were first synthesized in 1975 by Georges Köhler and César Milstein through the use of hybridoma technology. Later, in 1984, another milestone was achieved with the production of chimeric human antibodies via recombinant DNA technology. Hybridoma technology facilitates the creation of ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
One of the main obstacles in drug development is how to deliver drugs effectively to target cells. In general, macromolecules such as proteins and mRNA cannot penetrate the cell membrane because the cell membrane has acquired protective mechanisms through evolution. However, viruses can deliver their genetic material into cells. Therefore, viruses and virus-like particles are widely used to ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Diacylglycerol (DAG), also known as diglyceride, consists of two fatty acid chains and a glycerol molecule. It primarily exists in two forms: 1,2-diacylglycerol and 1,3-diacylglycerol. DAG can be synthesized via the phosphatidic acid pathway in the endoplasmic reticulum by the action of phosphatidic acid phosphatase or produced during the lipolysis of triglycerides (TAG) by TAG lipase. DAG is ...